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学科主题: 临床医学
题名:
Superior Graft-versus-Leukemia Effect Associated with Transplantation of Haploidentical Compared with HLA-Identical Sibling Donor Grafts for High-Risk Acute Leukemia: An Historic Comparison
作者: Wang, Yu; Liu, Dai-Hong; Xu, Lan-Ping; Liu, Kai-Yan; Chen, Huan; Chen, Yu-Hong; Han, Wei; Shi, Hong-Xia; Huang, Xiao-Jun
关键词: Hematopoietic stem cell transplantation ; HLA ; Mismatched
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2011-06-01
DOI: 10.1016/j.bbmt.2010.08.023
卷: 17, 期:6, 页:821-830
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; T-CELL ; HEMATOLOGIC MALIGNANCIES ; ANTITHYMOCYTE GLOBULIN ; UNRELATED DONORS ; MISMATCHED/HAPLOIDENTICAL BLOOD ; LYMPHOCYTE INFUSION ; PERIPHERAL-BLOOD ; HOST-DISEASE
英文摘要:

The outcomes of an historic comparison of 117 consecutive, high-risk, acute leukemia patients undergoing hematopoietic stem cell transplantation (HSCT) from HLA-mismatched/haploidentical donors (HID, n = 81) or HLA-identical sibling donors (ISD, n = 36) without the use of in vitro T cell depletion (TCD), between the period of January 2005 and April 2009 were compared. Full engraftment was achieved in 98% of patients in the HID group and 97% in the ISD group. The cumulative incidences of grades II-IV acute graft-versus-host disease (aGVHD) in the HID and ISD cohorts were 49% and 24%, respectively (P = .014) with a relative risk (RR) of 2.99 (1.25-7.21) (P = .014). The incidence of chronic GVHD (cGVHD) did not differ significantly between the 2 cohorts. The 2-year cumulative incidence of relapse was significantly lower in HID (26%) than in ISD patients (49%) (P = .008). The 2-year cumulative incidence of nonrelapse mortality (NRM) was comparable in recipients of HID (34%) and ISD grafts (38%) (P = .85). The 3-year probability of overall survival (OS) was higher in HID patients (42%) than in ISD (20%) (P = .048) patients. Our comparisons suggest that HID transplants can achieve a stronger graft-versus-leukemia (GVL) effect than ISD for high-risk acute leukemia patients. Biol Blood Marrow Transplant 17: 821-830 (2011) 2011 (C) American Society for Blood and Marrow Transplantation

语种: 英语
所属项目编号: 30725038 ; IRT 0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Program for innovative Research Team in University ; Leading Program of Clinical Faculty
WOS记录号: WOS:000291194000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65096
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Yu,Liu, Dai-Hong,Xu, Lan-Ping,et al. Superior Graft-versus-Leukemia Effect Associated with Transplantation of Haploidentical Compared with HLA-Identical Sibling Donor Grafts for High-Risk Acute Leukemia: An Historic Comparison[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2011,17(6):821-830.
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