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学科主题: 临床医学
题名:
Multiple sclerosis: clinical features and MRI findings in Northern China
作者: Li, Tianran1; Xiao, Hui2; Li, Shengjun3; Du, Xiangke4; Zhou, Jun1
关键词: Multiple sclerosis ; Conventional multiple sclerosis ; Optic-spinal cord multiple sclerosis ; Magnetic resonance imaging
刊名: EUROPEAN JOURNAL OF MEDICAL RESEARCH
发表日期: 2014-04-15
DOI: 10.1186/2047-783X-19-20
卷: 19
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: NEUROMYELITIS-OPTICA ; DIAGNOSTIC-CRITERIA ; NATIONWIDE SURVEY ; JAPANESE ; PHENOTYPES ; DISABILITY
英文摘要:

Background: Reports in Asian populations suggest that ethnic and geographical differences may influence susceptibility to multiple sclerosis (MS) and its clinical behaviors. Here, we sought to retrospectively survey clinical characteristics and MRI data in Chinese subjects with MS.

Methods: We conducted a retrospective analysis in 117 patients with MS. The patients were divided into subgroups with optic-spinal form of multiple sclerosis (OSMS; n = 42) and classical multiple sclerosis (CMS; n = 75). Clinical characteristics, MRI finding and expanded disability status scale (EDSS) score were compared between the two groups.

Results: In 117 MS patients, 64.1% patients were classified as having CMS and 35.9% OSMS forms. White blood cell counts of OSMS patients were significantly higher than those of CMS patients (P <0.05). The longitudinal fusion lesions of spinal cord on MRI were statistically significant between groups (P <0.05). Spinal cord MRI showed that MS lesions were longer, and revealed spinal cord swelling in patients with CMS, but atrophy in patients with OSMS. The EDSS score at five years was significantly higher in patients with OSMS than in those with CMS (P <0.05). Relapse rates of patients with OSMS were also higher than those of patients with CMS (P <0.01) within one to three years.

Conclusions: OSMS accounts for a higher proportion of MS populations in Northern China than in Western countries. MRI showed a longitudinally extensive spinal cord lesion in patients with OSMS and spinal cord swelling at onset.

语种: 英语
WOS记录号: WOS:000335180500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65099
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: 1.Fuzhou Gen Hosp, Affiliated Hosp 1, Dept Radiol, Putian 351100, Fujian Province, Peoples R China
2.Fuzhou Gen Hosp, Dept Radiol, Fuzhou 320025, Fujian Province, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
4.Jinan Gen Hosp, Dept Neurol, Jinan 250001, Shandong, India

Recommended Citation:
Li, Tianran,Xiao, Hui,Li, Shengjun,et al. Multiple sclerosis: clinical features and MRI findings in Northern China[J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH,2014,19.
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