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学科主题: 基础医学
题名:
Age-Dependent Down-Regulation of Mitochondrial 8-Oxoguanine DNA Glycosylase in SAM-P/8 Mouse Brain and Its Effect on Brain Aging
作者: Tian, Feng1; Tong, Tan-Jun1; Zhang, Zong-Yu1; McNutt, Michael A.2; Liu, Xin-Wen1
刊名: REJUVENATION RESEARCH
发表日期: 2009-06-01
DOI: 10.1089/rej.2009.0849
卷: 12, 期:3, 页:209-215
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology
研究领域[WOS]: Geriatrics & Gerontology
关键词[WOS]: PARKINSONS-DISEASE ; OXIDATIVE STRESS ; REPAIR ; MICE ; DYSFUNCTION ; DAMAGE
英文摘要:

Mitochondrial DNA (mtDNA) damage has been hypothesized to be responsible for aging and various neurological diseases. Abnormalities in 8-oxoguanine DNA glycosylase (OGG1) function can promote DNA oxidative damage, especially in the mitochondria. Here we report changes in the expression of OGG1 targeting to the nucleus, cytosol, and mitochondria in both accelerated senescence mice (SAM-P/8) and normal counterpart SAM-R/1 mice during brain aging. Our results showed that mRNA and protein levels of OGG1, especially OGG1 targeting to mitochondria, and the expression level of cytochrome c oxidase subunit III (COX III) in the brain of both SAM-P/8 mice and SAM-R/1 mice, decreased with age. However, such an age-dependent decrease in SAM-P/8 mice was larger than that in normal SAM-R/1 mice. These findings support the concept that down-regulation of OGG1, especially mitochondrial OGG1(mtOGG1) in SAM-P/8 mice, may promote brain aging by its effect on imbalance in the mtDNA damage repair systems, which leads to accumulation of mtDNA damage and oxidative phosphorylation-related protein dysfunction. Overall, our results provide novel insight into underlying the molecular mechanisms during brain aging.

语种: 英语
所属项目编号: 2007CB507401 ; 30671064
项目资助者: National Basic Research Programs of China ; National Nature Science Foundation of China
WOS记录号: WOS:000267929500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65102
Appears in Collections:基础医学院_北京大学衰老研究中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Tian, Feng,Tong, Tan-Jun,Zhang, Zong-Yu,et al. Age-Dependent Down-Regulation of Mitochondrial 8-Oxoguanine DNA Glycosylase in SAM-P/8 Mouse Brain and Its Effect on Brain Aging[J]. REJUVENATION RESEARCH,2009,12(3):209-215.
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