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学科主题基础医学
Age-Dependent Down-Regulation of Mitochondrial 8-Oxoguanine DNA Glycosylase in SAM-P/8 Mouse Brain and Its Effect on Brain Aging
Tian, Feng1; Tong, Tan-Jun1; Zhang, Zong-Yu1; McNutt, Michael A.2; Liu, Xin-Wen1
刊名REJUVENATION RESEARCH
2009-06-01
DOI10.1089/rej.2009.0849
12期:3页:209-215
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology
资助者National Basic Research Programs of China ; National Nature Science Foundation of China ; National Basic Research Programs of China ; National Nature Science Foundation of China
研究领域[WOS]Geriatrics & Gerontology
关键词[WOS]PARKINSONS-DISEASE ; OXIDATIVE STRESS ; REPAIR ; MICE ; DYSFUNCTION ; DAMAGE
英文摘要

Mitochondrial DNA (mtDNA) damage has been hypothesized to be responsible for aging and various neurological diseases. Abnormalities in 8-oxoguanine DNA glycosylase (OGG1) function can promote DNA oxidative damage, especially in the mitochondria. Here we report changes in the expression of OGG1 targeting to the nucleus, cytosol, and mitochondria in both accelerated senescence mice (SAM-P/8) and normal counterpart SAM-R/1 mice during brain aging. Our results showed that mRNA and protein levels of OGG1, especially OGG1 targeting to mitochondria, and the expression level of cytochrome c oxidase subunit III (COX III) in the brain of both SAM-P/8 mice and SAM-R/1 mice, decreased with age. However, such an age-dependent decrease in SAM-P/8 mice was larger than that in normal SAM-R/1 mice. These findings support the concept that down-regulation of OGG1, especially mitochondrial OGG1(mtOGG1) in SAM-P/8 mice, may promote brain aging by its effect on imbalance in the mtDNA damage repair systems, which leads to accumulation of mtDNA damage and oxidative phosphorylation-related protein dysfunction. Overall, our results provide novel insight into underlying the molecular mechanisms during brain aging.

语种英语
所属项目编号2007CB507401 ; 30671064
资助者National Basic Research Programs of China ; National Nature Science Foundation of China ; National Basic Research Programs of China ; National Nature Science Foundation of China
WOS记录号WOS:000267929500006
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65102
专题基础医学院_北京大学衰老研究中心
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
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Tian, Feng,Tong, Tan-Jun,Zhang, Zong-Yu,et al. Age-Dependent Down-Regulation of Mitochondrial 8-Oxoguanine DNA Glycosylase in SAM-P/8 Mouse Brain and Its Effect on Brain Aging[J]. REJUVENATION RESEARCH,2009,12(3):209-215.
APA Tian, Feng,Tong, Tan-Jun,Zhang, Zong-Yu,McNutt, Michael A.,&Liu, Xin-Wen.(2009).Age-Dependent Down-Regulation of Mitochondrial 8-Oxoguanine DNA Glycosylase in SAM-P/8 Mouse Brain and Its Effect on Brain Aging.REJUVENATION RESEARCH,12(3),209-215.
MLA Tian, Feng,et al."Age-Dependent Down-Regulation of Mitochondrial 8-Oxoguanine DNA Glycosylase in SAM-P/8 Mouse Brain and Its Effect on Brain Aging".REJUVENATION RESEARCH 12.3(2009):209-215.
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