学科主题基础医学
Synthesis of l-(alkoxymethyl)-5-benzyl-6-methyluracil as potential nonnucleoside HIV-1 RT inhibitors
Chen, Yanli; Guo, Ying; Yang, Hua; Wang, Xiaowei; Liu, Junyi
关键词HIV-1 reverse transcriptase nonnucleoside reverse transcriptase inhibitors N-1-alkylated-5-benzyl-6-methyluracil
刊名SYNTHETIC COMMUNICATIONS
2006
DOI10.1080/00397910600772850
36期:19页:2913-2920
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]DERIVATIVES
英文摘要

1,3-Dibenzyl-6-methyl-5-zincbromomethyluracil 6 was prepared starting from 6-methyluracil 1. The cross-coupling reaction of benzylic zinc reagent 6 with PhI using bis(dibenzylideneacetone) palladium( 0) and (o-furyl)(3)P as catalyst gave 1,3,5-tribenzyl-6-methyluracil 7. The N-1, N-3-dibenzyl group could be removed in dealkylation to give the 5-benzyl-6-methyluracil 8. It was N-1-alkylated with chloromethyl ethyl ether or chloromethyl benzyl ether to obtained the targets 9a and b. All synthesized compounds were tested for their inhibition of HIV-1 reverse transcriptase, and moderate activity were found for target compounds 9a and b and 5.

语种英语
WOS记录号WOS:000241196300019
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65103
专题北京大学基础医学院_生物化学与分子生物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Dept Biol Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yanli,Guo, Ying,Yang, Hua,et al. Synthesis of l-(alkoxymethyl)-5-benzyl-6-methyluracil as potential nonnucleoside HIV-1 RT inhibitors[J]. SYNTHETIC COMMUNICATIONS,2006,36(19):2913-2920.
APA Chen, Yanli,Guo, Ying,Yang, Hua,Wang, Xiaowei,&Liu, Junyi.(2006).Synthesis of l-(alkoxymethyl)-5-benzyl-6-methyluracil as potential nonnucleoside HIV-1 RT inhibitors.SYNTHETIC COMMUNICATIONS,36(19),2913-2920.
MLA Chen, Yanli,et al."Synthesis of l-(alkoxymethyl)-5-benzyl-6-methyluracil as potential nonnucleoside HIV-1 RT inhibitors".SYNTHETIC COMMUNICATIONS 36.19(2006):2913-2920.
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