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学科主题: 药学
题名:
Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension
作者: Feng, Fei-Fei1; Zhang, Dian-Rui1; Tian, Ke-Li2; Lou, Hai-Yan3; Qi, Xiao-Li2; Wang, Yan-Cai1; Duan, Cun-Xian1; Jia, Le-Jiao1; Wang, Fei-Hu1; Liu, Yue1; Zhang, Qiang4
关键词: Oridonin ; nanosuspension ; MCF-7 cells ; apoptosis
刊名: DRUG DELIVERY
发表日期: 2011-05-01
DOI: 10.3109/10717544.2010.536271
卷: 18, 期:4, 页:265-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SOLID LIPID NANOPARTICLES ; BCL-2 ; DRUGS
英文摘要:

The mechanism for anti-tumor activity of oridonin (ORI) nanosuspension, prepared by the high pressure homogenization method, was studied using MCF-7 human breast carcinoma cells in vitro. MTT assay, observation of morphologic changes, flow cytometric analysis, and western blot analysis indicated that ORI nanosuspension could significantly intensify the in vitro anti-tumor activity to MCF-7 cells, as compared with ORI solution. Furthermore, ORI nanosuspension induced G(2)/M stage proliferation arrest and apoptosis in MCF-7 cells depending on its concentration. In addition, western blot analysis indicated that the pro-caspase-3 protein was not cleaved into the activated form and the expression of anti-apoptotic Bcl-2 protein decreased, on the contrary, the expression of pro-apoptotic Bax protein increased in a dose-dependent manner in ORI nanosuspension-treated cells. These observations indicated that the anti-tumor activity of ORI nanosuspension was intensified by cell-cycle arrest and apoptosis induction.

语种: 英语
所属项目编号: 2009CB930300 ; 30672674
项目资助者: National Basic Research Program of China (973 Program) ; National Nature Science Foundation of China
WOS记录号: WOS:000288900100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65113
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Inst Biochem & Mol Biol, Sch Med, Jinan 250012, Shandong, Peoples R China
3.Shandong Univ, Dept Pharmacol, Sch Med, Jinan 250012, Shandong, Peoples R China
4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Feng, Fei-Fei,Zhang, Dian-Rui,Tian, Ke-Li,et al. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension[J]. DRUG DELIVERY,2011,18(4):265-271.
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