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学科主题临床医学
Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance
Sun, Lifang1,3; Wang, Jianliu1; Zhang, Lili3; Li, Xiaoping1; Shen, Danhua2
关键词Endometrial carcinoma Estrogen receptor-alpha 36 Clinical significance Biomarker
刊名GYNECOLOGIC AND OBSTETRIC INVESTIGATION
2013
DOI10.1159/000339933
75期:1页:68-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]BREAST-CANCER ; ER-ALPHA ; IDENTIFICATION ; CELLS
英文摘要

Objective: Estrogen receptor-alpha 36 (ER-alpha 36), a newly identified variant of ER-a, is predominantly membrane-based and mainly mediates nongenomic estrogen signaling. In this study, we investigated the expression of ER-alpha 36 in human endometrial carcinoma tissues to understand the relationship between its expression and clinicopathological characteristics. Methods: ER-alpha 36 expression was assessed by innmunostaining in 73 endometrial carcinomas, 20 normal endonnetrial tissues, and 9 with atypical endonnetrial hyperplasia. Correlations between ER-alpha 36 protein expression and clinicopathological characteristics were investigated. Results: The expression of ER-alpha 36 in endometrial carcinoma tissues was significantly lower than in normal endonnetrial tissues and atypical hyperplasia (p < 0.01). ER-alpha 36-negative tissues were significantly more likely than ER-alpha 36-positive tumors to have tumor involvement of the cervix (p < 0.05). The disease-free survival rate of patients with ER-alpha 36 expression was poorer than that of those who were negative for ER-alpha 36 expression (p < 0.01). There was no significant relationship between ER-alpha 36 expression and patient age, surgical staging, histological differentiation, myometrial invasion, lymph node metastasis, and pathological types (p > 0.05). Conclusions: ER-alpha 36 may be an important biomarker for diagnosis, prognostication, and treatment choice in endometrial carcinoma. copyright (c) 2012 S. Karger AG, Basel

语种英语
所属项目编号30571937
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000314256000011
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65115
Collection北京大学第二临床医学院_病理科
作者单位1.Peking Univ Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
2.Peking Univ Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
3.Beijing Jishuitan Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Sun, Lifang,Wang, Jianliu,Zhang, Lili,et al. Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance[J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION,2013,75(1):68-72.
APA Sun, Lifang,Wang, Jianliu,Zhang, Lili,Li, Xiaoping,&Shen, Danhua.(2013).Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance.GYNECOLOGIC AND OBSTETRIC INVESTIGATION,75(1),68-72.
MLA Sun, Lifang,et al."Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance".GYNECOLOGIC AND OBSTETRIC INVESTIGATION 75.1(2013):68-72.
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