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Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance
Sun, Lifang1,3; Wang, Jianliu1; Zhang, Lili3; Li, Xiaoping1; Shen, Danhua2
关键词Endometrial carcinoma Estrogen receptor-alpha 36 Clinical significance Biomarker
刊名GYNECOLOGIC AND OBSTETRIC INVESTIGATION
2013
DOI10.1159/000339933
75期:1页:68-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]BREAST-CANCER ; ER-ALPHA ; IDENTIFICATION ; CELLS
英文摘要

Objective: Estrogen receptor-alpha 36 (ER-alpha 36), a newly identified variant of ER-a, is predominantly membrane-based and mainly mediates nongenomic estrogen signaling. In this study, we investigated the expression of ER-alpha 36 in human endometrial carcinoma tissues to understand the relationship between its expression and clinicopathological characteristics. Methods: ER-alpha 36 expression was assessed by innmunostaining in 73 endometrial carcinomas, 20 normal endonnetrial tissues, and 9 with atypical endonnetrial hyperplasia. Correlations between ER-alpha 36 protein expression and clinicopathological characteristics were investigated. Results: The expression of ER-alpha 36 in endometrial carcinoma tissues was significantly lower than in normal endonnetrial tissues and atypical hyperplasia (p < 0.01). ER-alpha 36-negative tissues were significantly more likely than ER-alpha 36-positive tumors to have tumor involvement of the cervix (p < 0.05). The disease-free survival rate of patients with ER-alpha 36 expression was poorer than that of those who were negative for ER-alpha 36 expression (p < 0.01). There was no significant relationship between ER-alpha 36 expression and patient age, surgical staging, histological differentiation, myometrial invasion, lymph node metastasis, and pathological types (p > 0.05). Conclusions: ER-alpha 36 may be an important biomarker for diagnosis, prognostication, and treatment choice in endometrial carcinoma. copyright (c) 2012 S. Karger AG, Basel

语种英语
WOS记录号WOS:000314256000011
项目编号30571937
资助机构National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65115
专题北京大学第二临床医学院_病理科
作者单位1.Peking Univ Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
2.Peking Univ Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
3.Beijing Jishuitan Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
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Sun, Lifang,Wang, Jianliu,Zhang, Lili,et al. Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance[J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION,2013,75(1):68-72.
APA Sun, Lifang,Wang, Jianliu,Zhang, Lili,Li, Xiaoping,&Shen, Danhua.(2013).Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance.GYNECOLOGIC AND OBSTETRIC INVESTIGATION,75(1),68-72.
MLA Sun, Lifang,et al."Expression of ER-alpha 36, a Novel Variant of Estrogen Receptor in Endometrial Carcinoma and Its Clinical Significance".GYNECOLOGIC AND OBSTETRIC INVESTIGATION 75.1(2013):68-72.
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