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Microbial glycosylation of tanshinone IIA by Cunninghamella elegans AS 3.2028
Liang, Wen-fei; Li, Zi-wei; Ji, Shuai; Wang, Qi; Qiao, Xue; Guo, De-an; Ye, Min
刊名RSC ADVANCES
2015
DOI10.1039/c5ra09745b
5期:78页:63753-63756
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]Mass-spectrometry ; Derivatives ; Redox ; Nrf2 ; Rats
英文摘要

Tanshinone IIA (TIIA) is a natural product with significant anti-atherogenic activities. However, poor water-solubility and low bioavailability hinder its further exploitation as a drug candidate. In this study, microbial transformation of TIIA by Cunninghamella elegans AS 3.2028 was conducted to obtain two new glycosylated derivatives. Their structures were identified as hydroquinone TIIA 11-O-beta-D-glucopyranoside (1) and hydroquinone TIIA 12-O-beta-D-glucopyranoside (2) based on extensive NMR and MS spectral analyses. The solubility of 1 in 50% MeOH-H2O solution was approximately 50-fold that of TIIA, and 1 showed remarkably improved oral absorption in mice. Furthermore, 1 and 2 exhibited similar Nrf2 activation activity to TIIA.

语种英语
WOS记录号WOS:000358734800073
通讯作者邮箱yemin@bjmu.edu.cn
项目编号81222054 ; NCET-11-0019
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from Chinese Ministry of Education
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65116
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学药学院_分子与细胞药理学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liang, Wen-fei,Li, Zi-wei,Ji, Shuai,et al. Microbial glycosylation of tanshinone IIA by Cunninghamella elegans AS 3.2028[J]. RSC ADVANCES,2015,5(78):63753-63756.
APA Liang, Wen-fei.,Li, Zi-wei.,Ji, Shuai.,Wang, Qi.,Qiao, Xue.,...&Ye, Min.(2015).Microbial glycosylation of tanshinone IIA by Cunninghamella elegans AS 3.2028.RSC ADVANCES,5(78),63753-63756.
MLA Liang, Wen-fei,et al."Microbial glycosylation of tanshinone IIA by Cunninghamella elegans AS 3.2028".RSC ADVANCES 5.78(2015):63753-63756.
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