IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Dynamic changes in brain activations and functional connectivity during affectively different tactile stimuli
Hua, Qing-Ping1,2; Zeng, Xiang-Zhu3; Liu, Jian-Yu3; Wang, Jin-Yan1; Guo, Jian-You1; Luo, Fei1,2
关键词fMRI functional connectivity resting state pleasant touch unpleasant touch
刊名CELLULAR AND MOLECULAR NEUROBIOLOGY
2008
DOI10.1007/s10571-007-9228-z
28期:1页:57-70
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]ANTERIOR CINGULATE CORTEX ; HUMAN ORBITOFRONTAL CORTEX ; EVENT-RELATED FMRI ; MAGNETIC-RESONANCE ; RESTING-STATE ; INSULAR CORTEX ; PAIN ; REPRESENTATION ; AFFERENTS ; TOUCH
英文摘要

In the present study, we compared brain activations produced by pleasant, neutral and unpleasant touch, to the anterior lateral surface of lower leg of human subjects. It was found that several brain regions, including the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), as well as contralateral middle and posterior insula cortex were commonly activated under the three touch conditions. In addition, pleasant and unpleasant touch conditions shared a few brain regions including the contralateral posterior parietal cortex (PPC) and bilateral premotor cortex (PMC). Unpleasant touch specifically activated a set of pain-related brain regions such as contralateral supplementary motor area (SMA) and dorsal parts of bilateral anterior cingulated cortex, etc. Brain regions specifically activated by pleasant touch comprised bilateral lateral orbitofrontal cortex (OFC), posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), intraparietal cortex and left dorsal lateral prefrontal cortex (DLPFC). Using a novel functional connectivity model based on graph theory, we showed that a series of brain regions related to affectively different touch had significant functional connectivity during the resting state. Furthermore, it was found that such a network can be modulated between affectively different touch conditions.

语种英语
WOS记录号WOS:000253191800009
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65125
Collection北京大学基础医学院_神经生物学系
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100871, Peoples R China
3.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Hua, Qing-Ping,Zeng, Xiang-Zhu,Liu, Jian-Yu,et al. Dynamic changes in brain activations and functional connectivity during affectively different tactile stimuli[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(1):57-70.
APA Hua, Qing-Ping,Zeng, Xiang-Zhu,Liu, Jian-Yu,Wang, Jin-Yan,Guo, Jian-You,&Luo, Fei.(2008).Dynamic changes in brain activations and functional connectivity during affectively different tactile stimuli.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(1),57-70.
MLA Hua, Qing-Ping,et al."Dynamic changes in brain activations and functional connectivity during affectively different tactile stimuli".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.1(2008):57-70.
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