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Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities
Jiang, Shan1; Niu, Shan1; Zhao, Zhi-Hui2; Li, Zhong-Jun1; Li, Qing1
关键词Cell adhesion Heteroglycocluster Homoglycocluster Integrin alpha(M)beta(2) Synthesis
刊名CARBOHYDRATE RESEARCH
2015-09-23
DOI10.1016/j.carres.2015.06.002
414页:39-45
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]RECEPTOR-TYPE 3 ; CELL-ADHESION MOLECULES ; CROSS-METATHESIS ; LECTIN SITE ; LEUKOCYTE ; CD11B/CD18 ; NEUTROPHIL ; MECHANISMS ; INTEGRINS ; MIGRATION
英文摘要

A new series of mixed-type heteroglycoclusters containing mannose and lactose were synthesized. In the synthesis of rigid scaffold of heteroglycocluster, we found that trans-isomer could be prepared stereoselectively by means of Grubbs olefin cross-metathesis reactions. Moreover, sequential acylation using cyclic anhydride as scaffold could give cis-isomer. These two methods may provide complementarity of stereochemistry in heteroglycocluster assembling. The anti-adhesion activities of these compounds were assessed by Surface Plasmon Resonance (SPR) and static state cell-based adhesion assay. These results indicated that the rigid scaffold might not affect the anti-adhesion activities. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号NSFC: 90713004 ; 91213301 ; 21172015 ; 2009ZX09103044
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000361640700006
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65130
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Nanjing Normal Univ, Coll Life Sci, Jiangsu Prov Key Lab Mol & Med Biotechnol, Nanjing 210046, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Shan,Niu, Shan,Zhao, Zhi-Hui,et al. Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities[J]. CARBOHYDRATE RESEARCH,2015,414:39-45.
APA Jiang, Shan,Niu, Shan,Zhao, Zhi-Hui,Li, Zhong-Jun,&Li, Qing.(2015).Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities.CARBOHYDRATE RESEARCH,414,39-45.
MLA Jiang, Shan,et al."Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities".CARBOHYDRATE RESEARCH 414(2015):39-45.
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