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学科主题: 药学
题名:
Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities
作者: Jiang, Shan1; Niu, Shan1; Zhao, Zhi-Hui2; Li, Zhong-Jun1; Li, Qing1
关键词: Cell adhesion ; Heteroglycocluster ; Homoglycocluster ; Integrin alpha(M)beta(2) ; Synthesis
刊名: CARBOHYDRATE RESEARCH
发表日期: 2015-09-23
DOI: 10.1016/j.carres.2015.06.002
卷: 414, 页:39-45
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: RECEPTOR-TYPE 3 ; CELL-ADHESION MOLECULES ; CROSS-METATHESIS ; LECTIN SITE ; LEUKOCYTE ; CD11B/CD18 ; NEUTROPHIL ; MECHANISMS ; INTEGRINS ; MIGRATION
英文摘要:

A new series of mixed-type heteroglycoclusters containing mannose and lactose were synthesized. In the synthesis of rigid scaffold of heteroglycocluster, we found that trans-isomer could be prepared stereoselectively by means of Grubbs olefin cross-metathesis reactions. Moreover, sequential acylation using cyclic anhydride as scaffold could give cis-isomer. These two methods may provide complementarity of stereochemistry in heteroglycocluster assembling. The anti-adhesion activities of these compounds were assessed by Surface Plasmon Resonance (SPR) and static state cell-based adhesion assay. These results indicated that the rigid scaffold might not affect the anti-adhesion activities. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: NSFC: 90713004 ; 91213301 ; 21172015 ; 2009ZX09103044
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000361640700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65130
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Nanjing Normal Univ, Coll Life Sci, Jiangsu Prov Key Lab Mol & Med Biotechnol, Nanjing 210046, Jiangsu, Peoples R China

Recommended Citation:
Jiang, Shan,Niu, Shan,Zhao, Zhi-Hui,et al. Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities[J]. CARBOHYDRATE RESEARCH,2015,414:39-45.
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