|Computer-aided analysis with Image J for quantitatively assessing psoriatic lesion area|
|Sun, Z.; Wang, Y.; Ji, S.; Wang, K.; Zhao, Y.|
|关键词||psoriasis body surface area image J|
|刊名||SKIN RESEARCH AND TECHNOLOGY|
|WOS标题词||Science & Technology|
|关键词[WOS]||INVOLVED SURFACE-AREA ; SEVERITY INDEX ; DISEASE ; QUANTIFICATION ; ERYTHEMA ; IMPACT|
Background/aimsBody surface area is important in determining the severity of psoriasis. However, objective, reliable, and practical method is still in need for this purpose. We performed a computer image analysis (CIA) of psoriatic area using the image J freeware to determine whether this method could be used for objective evaluation of psoriatic area.
MethodsFifteen psoriasis patients were randomized to be treated with adalimumab or placebo in a clinical trial. At each visit, the psoriasis area of each body site was estimated by two physicians (E-method), and standard photographs were taken. The psoriasis area in the pictures was assessed with CIA using semi-automatic threshold selection (T-method), or manual selection (M-method, gold standard). The results assessed by the three methods were analyzed with reliability and affecting factors evaluated.
ResultsBoth T- and E-method correlated strongly with M-method, and T-method had a slightly stronger correlation with M-method. Both T- and E-methods had a good consistency between the evaluators. All the three methods were able to detect the change in the psoriatic area after treatment, while the E-method tends to overestimate.
ConclusionThe CIA with image J freeware is reliable and practicable in quantitatively assessing the lesional of psoriasis area.
|资助机构||National Natural Science Foundation of China|
|作者单位||Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100034, Peoples R China|
|Sun, Z.,Wang, Y.,Ji, S.,et al. Computer-aided analysis with Image J for quantitatively assessing psoriatic lesion area[J]. SKIN RESEARCH AND TECHNOLOGY,2015,21(4):437-443.|
|APA||Sun, Z.,Wang, Y.,Ji, S.,Wang, K.,&Zhao, Y..(2015).Computer-aided analysis with Image J for quantitatively assessing psoriatic lesion area.SKIN RESEARCH AND TECHNOLOGY,21(4),437-443.|
|MLA||Sun, Z.,et al."Computer-aided analysis with Image J for quantitatively assessing psoriatic lesion area".SKIN RESEARCH AND TECHNOLOGY 21.4(2015):437-443.|