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学科主题基础医学
AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries
Chai, Rui Chao1,2,3; Jiang, Jiao Hua1,2,3; Wong, Ann Yuen Kwan1,2,3; Jiang, Feng1,2,3; Gao, Kai1,2,3; Vatcher, Greg1,2,3; Yu, Albert Cheung Hoi1,2,3,4
关键词aquaporin ischemia MCAO scratch-wound stab-wound
刊名GLIA
2013-10-01
DOI10.1002/glia.22555
61期:10页:1748-1765
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者Beijing Natural Science Foundation ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AQUAPORIN WATER CHANNELS ; INNER MITOCHONDRIAL-MEMBRANE ; CENTRAL-NERVOUS-SYSTEM ; BRAIN EDEMA ; RAT ASTROCYTES ; REACTIVE ASTROCYTES ; ISCHEMIC-STROKE ; GENE-EXPRESSION ; CELL-MIGRATION ; PROTEIN
英文摘要

Water movement plays vital roles in both physiological and pathological conditions in the brain. Astrocytes are responsible for regulating this water movement and are the major contributors to brain edema in pathological conditions. Aquaporins (AQPs) in astrocytes play critical roles in the regulation of water movement in the brain. AQP1, 3, 4, 5, 8, and 9 have been reported in the brain. Compared with AQP1, 4, and 9, AQP3, 5, and 8 are less studied. Among the lesser known AQPs, AQP5, which has multiple functions identified outside the central nervous system, is also indicated to be involved in hypoxia injury in astrocytes. In our study, AQP5 expression could be detected both in primary cultures of astrocytes and neurons, and AQP5 expression in astrocytes was confirmed in 1- to 4-week old primary cultures of astrocytes. AQP5 was localized on the cytoplasmic membrane and in the cytoplasm of astrocytes. AQP5 expression was downregulated during ischemia treatment and upregulated after scratch-wound injury, which was also confirmed in a middle cerebral artery occlusion model and a stab-wound injury model in vivo. The AQP5 increased after scratch injury was polarized to the migrating processes and cytoplasmic membrane of astrocytes in the leading edge of the scratch-wound, and AQP5 over-expression facilitated astrocyte process elongation after scratch injury. Taken together, these results indicate that AQP5 might be an important water channel in astrocytes that is differentially expressed during various brain injuries. GLIA 2013;61:1748-1765

语种英语
所属项目编号7091004 ; 2011CB504400 ; 30870818 ; 31070974 ; 31171009 ; 81221002
资助者Beijing Natural Science Foundation ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China
WOS记录号WOS:000323451900015
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65141
专题基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Natl Hlth & Family Planning Commiss, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Inst Syst Biomed, Lab Translat Med, Beijing 100191, Peoples R China
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Chai, Rui Chao,Jiang, Jiao Hua,Wong, Ann Yuen Kwan,et al. AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries[J]. GLIA,2013,61(10):1748-1765.
APA Chai, Rui Chao.,Jiang, Jiao Hua.,Wong, Ann Yuen Kwan.,Jiang, Feng.,Gao, Kai.,...&Yu, Albert Cheung Hoi.(2013).AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries.GLIA,61(10),1748-1765.
MLA Chai, Rui Chao,et al."AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries".GLIA 61.10(2013):1748-1765.
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