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学科主题: 药学
题名:
In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus
作者: Sun, Chunguang1,2; Falagas, Matthew E.3,4,5; Wang, Rui1; Karageorgopoulos, Drosos E.3; Yu, Xuhong1; Liu, Youning6; Cai, Yun1; Liang, Beibei1; Song, Xiujie6; Liu, Zheyuan1
关键词: FICI ; fosfomycin ; minocycline ; MRSA ; synergism
刊名: JOURNAL OF ANTIBIOTICS
发表日期: 2011-08-01
DOI: 10.1038/ja.2011.52
卷: 64, 期:8, 页:559-562
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: HOSPITALIZED-PATIENTS ; UNITED-STATES ; SUSCEPTIBILITY ; TIGECYCLINE ; INFECTIONS ; EPIDEMIOLOGY ; VANCOMYCIN ; PROGRAM ; SENTRY ; MRSA
英文摘要:

This study aimed to evaluate the in vitro activity of minocycline combined with fosfomycin against isolates of methicillin-resistant Staphylococcus aureus (MRSA). A total of 87 clinical isolates of MRSA collected from three Chinese hospitals were included in the study. The checkerboard method with determination of the fractional IC index (FICI) was used to determine whether antibiotic combinations act synergistically against these isolates. The susceptibility results for minocycline and fosfomycin were interpreted according to the most relevant criteria. The results demonstrated the following interactions: 76 isolates (87.4%) showed synergistic interactions (FICI <= 0.5) and 11 isolates (12.6%) showed indifferent interactions (0.5= 4) were observed. The combination of minocycline and fosfomycin can be synergistic against MRSA. Further studies are required to determine the potential clinical role of this combination regimen as a therapeutic alternative for certain types of MRSA infections. The Journal of Antibiotics (2011) 64, 559-562; doi:10.1038/ja.2011.52; published online 20 July 2011

语种: 英语
所属项目编号: 2008ZX09312
项目资助者: Ministry of Science and Technology, China
WOS记录号: WOS:000294329300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65142
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Alfa Inst Biomed Sci, Athens, Greece
2.Henry Dunant Hosp, Dept Med, Athens, Greece
3.Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA
4.Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Beijing 100853, Peoples R China
5.Peking Univ, Dept Pharm Adm & Clin Pharm, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Pulm Dis, Beijing 100853, Peoples R China

Recommended Citation:
Sun, Chunguang,Falagas, Matthew E.,Wang, Rui,et al. In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus[J]. JOURNAL OF ANTIBIOTICS,2011,64(8):559-562.
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