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In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus
Sun, Chunguang1,2; Falagas, Matthew E.3,4,5; Wang, Rui1; Karageorgopoulos, Drosos E.3; Yu, Xuhong1; Liu, Youning6; Cai, Yun1; Liang, Beibei1; Song, Xiujie6; Liu, Zheyuan1
关键词FICI fosfomycin minocycline MRSA synergism
刊名JOURNAL OF ANTIBIOTICS
2011-08-01
DOI10.1038/ja.2011.52
64期:8页:559-562
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]HOSPITALIZED-PATIENTS ; UNITED-STATES ; SUSCEPTIBILITY ; TIGECYCLINE ; INFECTIONS ; EPIDEMIOLOGY ; VANCOMYCIN ; PROGRAM ; SENTRY ; MRSA
英文摘要

This study aimed to evaluate the in vitro activity of minocycline combined with fosfomycin against isolates of methicillin-resistant Staphylococcus aureus (MRSA). A total of 87 clinical isolates of MRSA collected from three Chinese hospitals were included in the study. The checkerboard method with determination of the fractional IC index (FICI) was used to determine whether antibiotic combinations act synergistically against these isolates. The susceptibility results for minocycline and fosfomycin were interpreted according to the most relevant criteria. The results demonstrated the following interactions: 76 isolates (87.4%) showed synergistic interactions (FICI <= 0.5) and 11 isolates (12.6%) showed indifferent interactions (0.5= 4) were observed. The combination of minocycline and fosfomycin can be synergistic against MRSA. Further studies are required to determine the potential clinical role of this combination regimen as a therapeutic alternative for certain types of MRSA infections. The Journal of Antibiotics (2011) 64, 559-562; doi:10.1038/ja.2011.52; published online 20 July 2011

语种英语
WOS记录号WOS:000294329300006
项目编号2008ZX09312
资助机构Ministry of Science and Technology, China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65142
专题北京大学药学院
作者单位1.Alfa Inst Biomed Sci, Athens, Greece
2.Henry Dunant Hosp, Dept Med, Athens, Greece
3.Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA
4.Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Beijing 100853, Peoples R China
5.Peking Univ, Dept Pharm Adm & Clin Pharm, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Pulm Dis, Beijing 100853, Peoples R China
推荐引用方式
GB/T 7714
Sun, Chunguang,Falagas, Matthew E.,Wang, Rui,et al. In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus[J]. JOURNAL OF ANTIBIOTICS,2011,64(8):559-562.
APA Sun, Chunguang.,Falagas, Matthew E..,Wang, Rui.,Karageorgopoulos, Drosos E..,Yu, Xuhong.,...&Liu, Zheyuan.(2011).In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus.JOURNAL OF ANTIBIOTICS,64(8),559-562.
MLA Sun, Chunguang,et al."In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus".JOURNAL OF ANTIBIOTICS 64.8(2011):559-562.
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