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学科主题: 公共卫生
题名:
The maternal combined supplementation of folic acid and Vitamin B-12 suppresses ethanol-induced developmental toxicity in mouse fetuses
作者: Xu, Yajun; Li, Yong; Tang, Yunan; Wang, Junbo; Shen, Xiaoyi; Long, Zhu; Zheng, Xiaoying
关键词: ethanol ; developmental toxicity ; folic acid ; vitamin B-12
刊名: REPRODUCTIVE TOXICOLOGY
发表日期: 2006-07-01
DOI: 10.1016/j.reprotox.2005.12.004
卷: 22, 期:1, 页:56-61
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Reproductive Biology ; Toxicology
研究领域[WOS]: Reproductive Biology ; Toxicology
关键词[WOS]: NEURAL-TUBE DEFECTS ; FETAL ALCOHOL SYNDROME ; FOLATE-DEFICIENCY ; RAT ; PREGNANCY ; RISK ; MICE ; HYPERHOMOCYSTEINEMIA ; MALABSORPTION ; HOMOCYSTEINE
英文摘要:

Maternal ethanol consumption during pregnancy can induce developmental defects in the fetus. The objective of this study was to assess whether combined supplementation of folic acid (FA) and Vitamin 1312 (VB12) in dams would suppress ethanol-induced developmental toxicity in CD-1 mice. Ethanol (5.0g/kg) was given intragastrically from gestational day (GD) 6 to GD15. Vitamin supplementation groups were additionally given 60.0 mg/kg FA, 1.0 mg/kg VB12, or 60.0 mg/kg FA + 1.0 mg/kg VB12 during GD1-16. The control group received distilled water only. Results of litter evaluation on GD18 showed that combined supplementation of FA and VB12 ameliorated many of the adverse effects of ethanol. In contrast, the single vitamin supplementation groups showed little or no amelioration. These results suggest that combined supplementation of FA and VB12 was more effective than each vitamin toward suppressing ethanol-induced developmental toxicity in CD-1 mice. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000239219600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65145
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Inst Populat Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Yajun,Li, Yong,Tang, Yunan,et al. The maternal combined supplementation of folic acid and Vitamin B-12 suppresses ethanol-induced developmental toxicity in mouse fetuses[J]. REPRODUCTIVE TOXICOLOGY,2006,22(1):56-61.
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