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The maternal combined supplementation of folic acid and Vitamin B-12 suppresses ethanol-induced developmental toxicity in mouse fetuses
Xu, Yajun; Li, Yong; Tang, Yunan; Wang, Junbo; Shen, Xiaoyi; Long, Zhu; Zheng, Xiaoying
关键词ethanol developmental toxicity folic acid vitamin B-12
刊名REPRODUCTIVE TOXICOLOGY
2006-07-01
DOI10.1016/j.reprotox.2005.12.004
22期:1页:56-61
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Reproductive Biology ; Toxicology
研究领域[WOS]Reproductive Biology ; Toxicology
关键词[WOS]NEURAL-TUBE DEFECTS ; FETAL ALCOHOL SYNDROME ; FOLATE-DEFICIENCY ; RAT ; PREGNANCY ; RISK ; MICE ; HYPERHOMOCYSTEINEMIA ; MALABSORPTION ; HOMOCYSTEINE
英文摘要

Maternal ethanol consumption during pregnancy can induce developmental defects in the fetus. The objective of this study was to assess whether combined supplementation of folic acid (FA) and Vitamin 1312 (VB12) in dams would suppress ethanol-induced developmental toxicity in CD-1 mice. Ethanol (5.0g/kg) was given intragastrically from gestational day (GD) 6 to GD15. Vitamin supplementation groups were additionally given 60.0 mg/kg FA, 1.0 mg/kg VB12, or 60.0 mg/kg FA + 1.0 mg/kg VB12 during GD1-16. The control group received distilled water only. Results of litter evaluation on GD18 showed that combined supplementation of FA and VB12 ameliorated many of the adverse effects of ethanol. In contrast, the single vitamin supplementation groups showed little or no amelioration. These results suggest that combined supplementation of FA and VB12 was more effective than each vitamin toward suppressing ethanol-induced developmental toxicity in CD-1 mice. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000239219600011
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65145
专题北京大学公共卫生学院
作者单位1.Peking Univ, Inst Populat Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
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GB/T 7714
Xu, Yajun,Li, Yong,Tang, Yunan,et al. The maternal combined supplementation of folic acid and Vitamin B-12 suppresses ethanol-induced developmental toxicity in mouse fetuses[J]. REPRODUCTIVE TOXICOLOGY,2006,22(1):56-61.
APA Xu, Yajun.,Li, Yong.,Tang, Yunan.,Wang, Junbo.,Shen, Xiaoyi.,...&Zheng, Xiaoying.(2006).The maternal combined supplementation of folic acid and Vitamin B-12 suppresses ethanol-induced developmental toxicity in mouse fetuses.REPRODUCTIVE TOXICOLOGY,22(1),56-61.
MLA Xu, Yajun,et al."The maternal combined supplementation of folic acid and Vitamin B-12 suppresses ethanol-induced developmental toxicity in mouse fetuses".REPRODUCTIVE TOXICOLOGY 22.1(2006):56-61.
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