IR@PKUHSC  > 北京大学第三临床医学院  > 呼吸科
学科主题临床医学
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
Martinez, Carlos H.; Chen, Ya-Hong2; Westgate, Phillip M.3; Liu, Lyrica X.3; Murray, Susan3; Curtis, Jeffrey L.4; Make, Barry J.5; Kazerooni, Ella A.6; Lynch, David A.5,7; Marchetti, Nathaniel8; Washko, George R.9; Martinez, Fernando J.; Han, MeiLan K.1; COPDGene Investigators
刊名THORAX
2012-05-01
DOI10.1136/thoraxjnl-2011-201185
67期:5页:399-406
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
研究领域[WOS]Respiratory System
关键词[WOS]VOLUME-REDUCTION SURGERY ; AIRWAY DIMENSIONS ; EMPHYSEMA ; COPD ; CAPACITY ; INDEX
英文摘要

Background The value of quantitative CT (QCT) to identify chronic obstructive pulmonary disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George′s Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE).

Methods 1200 COPDGene subjects meeting Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for COPD with QCT analysis were included. Total lung emphysema was measured using the density mask technique with a -950 Hounsfield unit threshold. An automated programme measured mean wall thickness (WT), wall area percentage (WA%) and 10 mm lumenal perimeter (pi10) in six segmental bronchi. Separate multivariate analyses examined the relative influence of airway measures and emphysema on SGRQ and BODE.

Results In separate models predicting SGRQ score, a 1 unit SD increase in each airway measure predicted higher SGRQ scores (for WT, 1.90 points higher, p=0.002; for WA%, 1.52 points higher, p=0.02; for pi10, 2.83 points higher p<0.001). The comparable increase in SGRQ for a 1 unit SD increase in emphysema percentage in these models was relatively weaker, significant only in the pi10 model (for emphysema percentage, 1.45 points higher, p=0.01). In separate models predicting BODE, a 1 unit SD increase in each airway measure predicted higher BODE scores (for WT, 1.07-fold increase, p<0.001; for WA%, 1.20-fold increase, p<0.001; for pi10, 1.16-fold increase, p<0.001). In these models, emphysema more strongly influenced BODE (range 1.24-1.26-fold increase, p<0.001).

Conclusion Emphysema and airway disease both relate to clinically important parameters. The relative influence of airway disease is greater for SGRQ; the relative influence of emphysema is greater for BODE.

语种英语
WOS记录号WOS:000302959000008
项目编号U01HL089897 ; U01Hl089856 ; K23 HL093351 ; K23 HL089353
资助机构NHLBI ; Parker B. Francis Foundation ; COPD Foundation
引用统计
被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65149
专题北京大学第三临床医学院_呼吸科
作者单位1.Peking Univ, Hosp 3, Resp Dept, Beijing 100871, Peoples R China
2.VA Ann Arbor Healthcare Syst, Med Serv, Ann Arbor, MI USA
3.Univ Michigan Hlth Syst, Div Pulm & Crit Care Med, Taubman Ctr 3916, Ann Arbor, MI 48109 USA
4.Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
5.Univ Michigan Hlth Syst, Dept Radiol, Ann Arbor, MI 48109 USA
6.Temple Univ, Philadelphia, PA 19122 USA
7.Brigham & Womens Hosp, Pulm & Crit Care Div, Boston, MA 02115 USA
8.Natl Jewish Hlth, Dept Med, Denver, CO USA
9.Natl Jewish Hlth, Div Radiol, Denver, CO USA
推荐引用方式
GB/T 7714
Martinez, Carlos H.,Chen, Ya-Hong,Westgate, Phillip M.,et al. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease[J]. THORAX,2012,67(5):399-406.
APA Martinez, Carlos H..,Chen, Ya-Hong.,Westgate, Phillip M..,Liu, Lyrica X..,Murray, Susan.,...&COPDGene Investigators.(2012).Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease.THORAX,67(5),399-406.
MLA Martinez, Carlos H.,et al."Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease".THORAX 67.5(2012):399-406.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Martinez, Carlos H.]的文章
[Chen, Ya-Hong]的文章
[Westgate, Phillip M.]的文章
百度学术
百度学术中相似的文章
[Martinez, Carlos H.]的文章
[Chen, Ya-Hong]的文章
[Westgate, Phillip M.]的文章
必应学术
必应学术中相似的文章
[Martinez, Carlos H.]的文章
[Chen, Ya-Hong]的文章
[Westgate, Phillip M.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。