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Characterization of phenolic compounds in the crude extract of Hedysarum multilugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry
Yang, Min; Wang, Wei; Sun, Jianghao; Zhao, Yuying; Liu, Yi; Liang, Hong; Guo, De-an
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2007
DOI10.1002/rcm.3277
21期:23页:3833-3841
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]MULTIJUGUM ; FLAVONOIDS ; ROOTS
英文摘要

The fragmentation behavior of four types of phenolic compounds: coumestans, pterocarpenes, benzofurans and isoflavones, were studied using electrospray ionization multistage mass spectrometry (ESI-MSn) (n = 2-5) in negative ion mode. Losses of methyl (15 Da), CO (28 Da), CO2 (44 Da), isopropyl (43 Da) and isobutenyl (55 Da) were dominating fragmentation patterns. Different positions and numbers of the substituents also led to the different fragmentation behavior. These fragmentation rules were applied for the identification of constituents in methanolic extracts of Hedysarum multijugum, in which 29 compounds were characterized, including nine new compounds. The method established in this study could be applied to the comprehensive quality control of the herb and its formulations. It could also be applied to the biological and pharmacological research of traditional Chinese medicines. Copyright (c) 2007 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000251287200009
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65150
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Yang, Min,Wang, Wei,Sun, Jianghao,et al. Characterization of phenolic compounds in the crude extract of Hedysarum multilugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2007,21(23):3833-3841.
APA Yang, Min.,Wang, Wei.,Sun, Jianghao.,Zhao, Yuying.,Liu, Yi.,...&Guo, De-an.(2007).Characterization of phenolic compounds in the crude extract of Hedysarum multilugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,21(23),3833-3841.
MLA Yang, Min,et al."Characterization of phenolic compounds in the crude extract of Hedysarum multilugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 21.23(2007):3833-3841.
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