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学科主题: 临床医学
题名:
In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy
作者: Zhao, J; Ding, HS; Hou, XL; Le Zhou, C; Chance, B
关键词: near-infrared spectroscopy ; frequency domain ; brain ; infant
刊名: JOURNAL OF BIOMEDICAL OPTICS
发表日期: 2005-03-01
DOI: 10.1117/1.1891345
卷: 10, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: PHOTON-DENSITY WAVES ; STRONGLY SCATTERING MEDIA ; TIME-RESOLVED REFLECTANCE ; PIGLET BRAIN ; NONINVASIVE MEASUREMENT ; TISSUE ; INSTRUMENT ; ABSORPTION ; MIGRATION ; PROPAGATION
英文摘要:

We investigate the optical properties of the brain in 23 neonates in vivo using a frequency domain near-infrared spectroscopy (NIRS). In this study, a calibration procedure is employed to determine the absorption and reduced scattering coefficients with single source-detector separation. The absorption coefficients of the infant foreheads are lower than the values reported in adults. A large intersubject variation in the reduced scattering coefficients is also demonstrated. Furthermore, physiological parameters are derived from the absorption coefficients at two wavelengths (788 and 832 nm). The mean total hemoglobin concentration (THC) is 39.7 +/- 9.8 mu M and the mean cerebral blood oxygen saturation (StO(2)) is 58.7 +/- 11.2%. Our preliminary results show that this bedside frequent domain NIRS could provide quantitative optical measurement of the infant brain. (c) 2005 SocietyofPhoto-Optical instrumentation Engineers.

语种: 英语
WOS记录号: WOS:000232570200027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65152
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Tsing Hua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

Recommended Citation:
Zhao, J,Ding, HS,Hou, XL,et al. In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy[J]. JOURNAL OF BIOMEDICAL OPTICS,2005,10(2).
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