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学科主题临床医学
In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy
Zhao, J; Ding, HS; Hou, XL; Le Zhou, C; Chance, B
关键词near-infrared spectroscopy frequency domain brain infant
刊名JOURNAL OF BIOMEDICAL OPTICS
2005-03-01
DOI10.1117/1.1891345
10期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]PHOTON-DENSITY WAVES ; STRONGLY SCATTERING MEDIA ; TIME-RESOLVED REFLECTANCE ; PIGLET BRAIN ; NONINVASIVE MEASUREMENT ; TISSUE ; INSTRUMENT ; ABSORPTION ; MIGRATION ; PROPAGATION
英文摘要

We investigate the optical properties of the brain in 23 neonates in vivo using a frequency domain near-infrared spectroscopy (NIRS). In this study, a calibration procedure is employed to determine the absorption and reduced scattering coefficients with single source-detector separation. The absorption coefficients of the infant foreheads are lower than the values reported in adults. A large intersubject variation in the reduced scattering coefficients is also demonstrated. Furthermore, physiological parameters are derived from the absorption coefficients at two wavelengths (788 and 832 nm). The mean total hemoglobin concentration (THC) is 39.7 +/- 9.8 mu M and the mean cerebral blood oxygen saturation (StO(2)) is 58.7 +/- 11.2%. Our preliminary results show that this bedside frequent domain NIRS could provide quantitative optical measurement of the infant brain. (c) 2005 SocietyofPhoto-Optical instrumentation Engineers.

语种英语
WOS记录号WOS:000232570200027
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65152
专题北京大学第一临床医学院_儿科
作者单位1.Tsing Hua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
推荐引用方式
GB/T 7714
Zhao, J,Ding, HS,Hou, XL,et al. In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy[J]. JOURNAL OF BIOMEDICAL OPTICS,2005,10(2).
APA Zhao, J,Ding, HS,Hou, XL,Le Zhou, C,&Chance, B.(2005).In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy.JOURNAL OF BIOMEDICAL OPTICS,10(2).
MLA Zhao, J,et al."In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy".JOURNAL OF BIOMEDICAL OPTICS 10.2(2005).
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