IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer
Ke, Hengte1,2,3; Yue, Xiuli3; Wang, Jinrui1,2; Xing, Sen3; Zhang, Qian4; Dai, Zhifei1,2; Tian, Jie5; Wang, Shumin1,2; Jin, Yushen3
关键词gold nanoshell liquid perfluorocarbon ultrasound imaging CT imaging photothermal therapy
刊名SMALL
2014-03-01
DOI10.1002/smll.201302252
10期:6页:1220-1227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]RAY COMPUTED-TOMOGRAPHY ; CONTRAST AGENTS ; MACROPHAGE ENDOCYTOSIS ; OPTICAL-PROPERTIES ; NANOPARTICLES ; HYPERTHERMIA ; RADIATION ; NANOCAGES ; NANORODS ; TUMORS
英文摘要

The integration of multimodal contrast-enhanced diagnostic imaging and therapeutic capabilities could utilize imaging guided therapy to plan the treatment strategy based on the diagnostic results and to guide/monitor the therapeutic procedures. Herein, gold nanoshelled perfluorooctylbromide (PFOB) nanocapsules with PEGylation (PGsP NCs) are constructed by oil-in-water emulsion method to form polymeric PFOB nanocapsules, followed by the formation of PEGylated gold nanoshell on the surface. PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as efficient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model. To our best knowledge, this is the first report of gold nanoshell serving as both CT contrast agents and photoabsorbers for photothermal therapy. The novel multifunctional nanomedicine would be of great value to offer more comprehensive diagnostic information to guide more accurate and effective cancer therapy.

语种英语
WOS记录号WOS:000333538000024
项目编号81225011 ; 81230036 ; 81371580 ; 21273014 ; 81101094
资助机构National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65153
专题北京大学第三临床医学院
作者单位1.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Life Sci & Technol, Harbin 150080, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
3.Chinese Acad Sci, Intelligent Med Ctr, Inst Automat, Beijing 100190, Peoples R China
4.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ke, Hengte,Yue, Xiuli,Wang, Jinrui,et al. Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer[J]. SMALL,2014,10(6):1220-1227.
APA Ke, Hengte.,Yue, Xiuli.,Wang, Jinrui.,Xing, Sen.,Zhang, Qian.,...&Jin, Yushen.(2014).Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer.SMALL,10(6),1220-1227.
MLA Ke, Hengte,et al."Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer".SMALL 10.6(2014):1220-1227.
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