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学科主题: 临床医学
题名:
Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer
作者: Ke, Hengte1,2,3; Yue, Xiuli3; Wang, Jinrui1,2; Xing, Sen3; Zhang, Qian4; Dai, Zhifei1,2; Tian, Jie5; Wang, Shumin1,2; Jin, Yushen3
关键词: gold nanoshell ; liquid perfluorocarbon ; ultrasound imaging ; CT imaging ; photothermal therapy
刊名: SMALL
发表日期: 2014-03-01
DOI: 10.1002/smll.201302252
卷: 10, 期:6, 页:1220-1227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: RAY COMPUTED-TOMOGRAPHY ; CONTRAST AGENTS ; MACROPHAGE ENDOCYTOSIS ; OPTICAL-PROPERTIES ; NANOPARTICLES ; HYPERTHERMIA ; RADIATION ; NANOCAGES ; NANORODS ; TUMORS
英文摘要:

The integration of multimodal contrast-enhanced diagnostic imaging and therapeutic capabilities could utilize imaging guided therapy to plan the treatment strategy based on the diagnostic results and to guide/monitor the therapeutic procedures. Herein, gold nanoshelled perfluorooctylbromide (PFOB) nanocapsules with PEGylation (PGsP NCs) are constructed by oil-in-water emulsion method to form polymeric PFOB nanocapsules, followed by the formation of PEGylated gold nanoshell on the surface. PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as efficient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model. To our best knowledge, this is the first report of gold nanoshell serving as both CT contrast agents and photoabsorbers for photothermal therapy. The novel multifunctional nanomedicine would be of great value to offer more comprehensive diagnostic information to guide more accurate and effective cancer therapy.

语种: 英语
所属项目编号: 81225011 ; 81230036 ; 81371580 ; 21273014 ; 81101094
项目资助者: National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
WOS记录号: WOS:000333538000024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65153
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Life Sci & Technol, Harbin 150080, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
3.Chinese Acad Sci, Intelligent Med Ctr, Inst Automat, Beijing 100190, Peoples R China
4.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Ke, Hengte,Yue, Xiuli,Wang, Jinrui,et al. Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer[J]. SMALL,2014,10(6):1220-1227.
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