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Development and characteristics of temperature-sensitive liposomes for vinorelbine bitartrate
Zhang, Hui1; Wang, Zhi-yuan1; Gong, Wei1; Li, Zhi-ping1; Mei, Xing-guo1; Lv, Wan-liang2
关键词Temperature-sensitive Liposomes Vinorelbine pH gradient Thin film hydration Hyperthermia
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2011-07-29
DOI10.1016/j.ijpharm.2011.05.013
414期:1-2页:56-62
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TUMOR XENOGRAFT MODEL ; DRUG-RELEASE ; LOCAL HYPERTHERMIA ; THERMOSENSITIVE LIPOSOMES ; REGIONAL HYPERTHERMIA ; SOFT-TISSUE ; DOXORUBICIN ; DELIVERY ; MURINE ; PHARMACOKINETICS
英文摘要

A novel liposome with temperature-sensitivity for vinorelbine bitartrate (VB) was designed to enhance VB targeted delivery and antitumor effect. Liposomes without drugs were prepared by thin film hydration, and then VB was entrapped into liposomes by pH gradient loading method. The mean particle size of the liposomes was about 100 nm, and the drug entrapment efficiency was more than 90%. Stability data indicated that the liposome was physically and chemically stable for at least 6 months at 4 degrees C. In vitro drug release study showed that drugs hardly released at 37 degrees C; while at 42 degrees C. drugs released quickly. For in vivo experiments, the lung tumor model was established by subcutaneous inoculation of cell suspension on mice, liposomes and free VB were injected i.v. in mice, followed by exposure the tumors to hyperthermia (HT) for 30 min after administration. The ratio of inhibition tumor of temperature-sensitive liposomes group was significantly higher than the normal injection group. Combining temperature-sensitive liposomes with HT enhanced the delivery of VB and, consequently, its antitumor effects. This liposome could potentially produce viable clinical strategies for improved targeting and delivery of VB for treatment of cancer. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000292795500008
项目编号2007CB935800 ; 2009ZX09301-002
资助机构Major State Basic Research Development Program of China ; Important National Science &amp ; Technology Specific Projects
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65154
专题北京大学药学院
作者单位1.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, Hui,Wang, Zhi-yuan,Gong, Wei,et al. Development and characteristics of temperature-sensitive liposomes for vinorelbine bitartrate[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2011,414(1-2):56-62.
APA Zhang, Hui,Wang, Zhi-yuan,Gong, Wei,Li, Zhi-ping,Mei, Xing-guo,&Lv, Wan-liang.(2011).Development and characteristics of temperature-sensitive liposomes for vinorelbine bitartrate.INTERNATIONAL JOURNAL OF PHARMACEUTICS,414(1-2),56-62.
MLA Zhang, Hui,et al."Development and characteristics of temperature-sensitive liposomes for vinorelbine bitartrate".INTERNATIONAL JOURNAL OF PHARMACEUTICS 414.1-2(2011):56-62.
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