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学科主题基础医学
DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation
Liu, Haijing; Ling, Yun; Gong, Yilei; Sun, Ying; Hou, Lin; Zhang, Bo
关键词N-acetyltransferase transcription regulation expression DNA damage
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2007-06-01
DOI10.1007/s11010-006-9390-5
300期:1-2页:249-258
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]STRAND BREAK REPAIR ; TELOMERASE ; CELLS ; CANCER ; STABILITY ; APOPTOSIS ; KINASE ; HTERT
英文摘要

NAT10 (N-acetyltransferase 10) is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity. The presented research shows its transcriptional activation by genotoxic agents and possible role in DNA damage. NAT10 mRNA could be markedly increased by using hydrogen peroxide (H2O2) or cisplatin in a dose- and time-dependent way, and the immunofluorescent staining revealed that the treatment of H2O2 or cisplatin induced focal accumulation of NAT10 protein in cellular nuclei. Both H2O2 and cisplatin could stimulate the transcriptional activity of the NAT10 promoter through the upstream sequences from -615 bp to +110 bp, with which some nuclear proteins interacted. Ectopic expression of NAT10 could enhance the number of survival cells in the presence of H2O2 or cisplatin. The above results suggested that NAT10 could be involved in DNA damage response and increased cellular resistance to genotoxicity.

语种英语
WOS记录号WOS:000247387300026
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65155
专题北京大学基础医学院_病理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
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GB/T 7714
Liu, Haijing,Ling, Yun,Gong, Yilei,et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,300(1-2):249-258.
APA Liu, Haijing,Ling, Yun,Gong, Yilei,Sun, Ying,Hou, Lin,&Zhang, Bo.(2007).DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation.MOLECULAR AND CELLULAR BIOCHEMISTRY,300(1-2),249-258.
MLA Liu, Haijing,et al."DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation".MOLECULAR AND CELLULAR BIOCHEMISTRY 300.1-2(2007):249-258.
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