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学科主题: 基础医学
题名:
DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation
作者: Liu, Haijing; Ling, Yun; Gong, Yilei; Sun, Ying; Hou, Lin; Zhang, Bo
关键词: N-acetyltransferase ; transcription regulation ; expression ; DNA damage
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2007-06-01
DOI: 10.1007/s11010-006-9390-5
卷: 300, 期:1-2, 页:249-258
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: STRAND BREAK REPAIR ; TELOMERASE ; CELLS ; CANCER ; STABILITY ; APOPTOSIS ; KINASE ; HTERT
英文摘要:

NAT10 (N-acetyltransferase 10) is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity. The presented research shows its transcriptional activation by genotoxic agents and possible role in DNA damage. NAT10 mRNA could be markedly increased by using hydrogen peroxide (H2O2) or cisplatin in a dose- and time-dependent way, and the immunofluorescent staining revealed that the treatment of H2O2 or cisplatin induced focal accumulation of NAT10 protein in cellular nuclei. Both H2O2 and cisplatin could stimulate the transcriptional activity of the NAT10 promoter through the upstream sequences from -615 bp to +110 bp, with which some nuclear proteins interacted. Ectopic expression of NAT10 could enhance the number of survival cells in the presence of H2O2 or cisplatin. The above results suggested that NAT10 could be involved in DNA damage response and increased cellular resistance to genotoxicity.

语种: 英语
WOS记录号: WOS:000247387300026
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65155
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Haijing,Ling, Yun,Gong, Yilei,et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,300(1-2):249-258.
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