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学科主题临床医学
Earlier Blood Pressure-Lowering and Greater Attenuation of Hematoma Growth in Acute Intracerebral Hemorrhage INTERACT Pilot Phase
Arima, Hisatomi1,2; Huang, Yining3; Wang, Ji Guang4; Heeley, Emma1,2; Delcourt, Candice1,2; Parsons, Mark5; Li, Qiang1,2; Neal, Bruce1,2; Chalmers, John1,2; Anderson, Craig1,2; INTERACT1 Investigators
关键词blood pressure-lowering clinical trials INTERACT intracerebral hemorrhage time
刊名STROKE
2012-08-01
DOI10.1161/STROKEAHA.112.651422
43期:8页:2236-U429
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Peripheral Vascular Disease
资助者National Health and Medical Research Council ; National Health and Medical Research Council
研究领域[WOS]Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]ACTIVATED FACTOR-VII ; PERIHEMATOMAL EDEMA ; REDUCTION ; TRIAL
英文摘要

Background and Purpose-The INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT) pilot study showed that early intensive blood pressure-lowering can attenuate hematoma growth in acute intracerebral hemorrhage. The present analysis aimed to determine the treatment effects on hematoma growth by time from intracerebral hemorrhage onset to randomization.

Methods-Patients (N = 404) with acute intracerebral hemorrhage and elevated systolic blood pressure were randomly assigned to intensive or guideline-based blood pressure management. Baseline and repeat CT (24 and 72 hours) were performed and changes in hematoma volume were assessed using generalized estimating equations.

Results-Among 296 patients with all 3 CT scans available for analysis, reductions in proportional hematoma growth produced by randomized intensive blood pressure-lowering treatment over 72 hours decreased progressively with delays in initiation of study treatment: 22%, 17%, 9%, and 3% for quartile groups defined by time from onset to randomization of <2.9, 2.9 to 3.6, 3.7 to 4.8, and >= 4.9 hours, respectively (P trend = 0.001). There were also smaller absolute reductions in hematoma growth with delays in initiation of study treatment (6.5 mL, 3.3 mL, 0.9 mL, and 0.6 mL), although the trend did not reach statistical significance (P trend = 0.12).

Conclusions-Earlier initiation of intensive blood pressure-lowering treatment is likely to provide greater protection against hematoma growth in acute intracerebral hemorrhage.

语种英语
所属项目编号358395
资助者National Health and Medical Research Council ; National Health and Medical Research Council
WOS记录号WOS:000306689300046
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65158
专题北京大学第一临床医学院
作者单位1.Univ Sydney, Sydney, NSW 2006, Australia
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
3.Royal Prince Alfred Hosp, George Inst Global Hlth, Sydney, NSW 2050, Australia
4.Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Rui Jin Hosp, Sch Med, Shanghai 200030, Peoples R China
5.John Hunter Hosp, Dept Neurol, Hunter Med Res Inst, Newcastle, NSW, Australia
推荐引用方式
GB/T 7714
Arima, Hisatomi,Huang, Yining,Wang, Ji Guang,et al. Earlier Blood Pressure-Lowering and Greater Attenuation of Hematoma Growth in Acute Intracerebral Hemorrhage INTERACT Pilot Phase[J]. STROKE,2012,43(8):2236-U429.
APA Arima, Hisatomi.,Huang, Yining.,Wang, Ji Guang.,Heeley, Emma.,Delcourt, Candice.,...&INTERACT1 Investigators.(2012).Earlier Blood Pressure-Lowering and Greater Attenuation of Hematoma Growth in Acute Intracerebral Hemorrhage INTERACT Pilot Phase.STROKE,43(8),2236-U429.
MLA Arima, Hisatomi,et al."Earlier Blood Pressure-Lowering and Greater Attenuation of Hematoma Growth in Acute Intracerebral Hemorrhage INTERACT Pilot Phase".STROKE 43.8(2012):2236-U429.
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