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学科主题: 临床医学
题名:
Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer
作者: Dong, Ningning1; Wang, Mingyu2; Li, Huiqing3; Cui, Yongchun4; Guo, Qisen2
关键词: Gemcitabine ; Vinorelbine ; Chemotherapy ; Elder ; Metastatic breast cancer
刊名: CANCER CHEMOTHERAPY AND PHARMACOLOGY
发表日期: 2012-05-01
DOI: 10.1007/s00280-012-1830-1
卷: 69, 期:5, 页:1315-1322
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pharmacology & Pharmacy
研究领域[WOS]: Oncology ; Pharmacology & Pharmacy
关键词[WOS]: PHASE-II ; 1ST-LINE CHEMOTHERAPY ; 2ND-LINE TREATMENT ; CLINICAL-TRIALS ; MONOTHERAPY ; AGE ; CAPECITABINE ; EFFICACY ; SAFETY ; OLDER
英文摘要:

To evaluate the efficacy and safety of gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer (MBC).

Elderly patients with MBC received gemcitabine 1,000 mg m(-2) and vinorelbine 25 mg m(-2) on days 1 and 8 every 3 weeks for a maximum of 6 cycles. The primary end points were objective response and toxicity. The secondary end points included progression-free survival (PFS), overall survival (OS), and prognostic factors associated with disease control, PFS, and OS.

Fifty-one patients with a median age of 73 years (range, 65-84 years) were included. The response rate according to Response Evaluation Criteria in Solid Tumors was 33.3% (95% confidence interval [CI], 20.4 to 46.2%). At a median follow-up of 16.2 months, median PFS and OS were 6.2 (95% CI, 4.6 to 7.8) and 17.0 months (95% CI, 14.5 to 19.5), respectively. Grade 3 to 4 adverse events included neutropenia (25.5%), anemia (13.7%), thrombocytopenia (9.8%), fatigue (5.9%), constipation (3.9%), neuropathy (3.9%), and hepatotoxicity (3.9%). Neutropenic fever occurred in 2 patients. There was one toxic death due to massive gastrointestinal hemorrhage. The study of prognostic factors did not reveal any predictive factor of disease control, while response to treatment and Eastern Cooperative Oncology Group performance status was the main factor conditioning PFS and OS, respectively.

Gemcitabine in combination with vinorelbine is active and safe in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer.

语种: 英语
WOS记录号: WOS:000303418500023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65165
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Med Oncol Dept,Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Shandong Tumor Hosp & Inst, Dept Chemotherapy, Jinan 250117, Peoples R China
3.Shandong Acad Med Sci, Inst Basic Med, Dept Epidemiol, Jinan 250062, Peoples R China
4.Shandong Tumor Hosp & Inst, Clin Trial Ctr, Jinan 250117, Peoples R China

Recommended Citation:
Dong, Ningning,Wang, Mingyu,Li, Huiqing,et al. Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY,2012,69(5):1315-1322.
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