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Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer
Dong, Ningning1; Wang, Mingyu2; Li, Huiqing3; Cui, Yongchun4; Guo, Qisen2
关键词Gemcitabine Vinorelbine Chemotherapy Elder Metastatic breast cancer
刊名CANCER CHEMOTHERAPY AND PHARMACOLOGY
2012-05-01
DOI10.1007/s00280-012-1830-1
69期:5页:1315-1322
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pharmacology & Pharmacy
研究领域[WOS]Oncology ; Pharmacology & Pharmacy
关键词[WOS]PHASE-II ; 1ST-LINE CHEMOTHERAPY ; 2ND-LINE TREATMENT ; CLINICAL-TRIALS ; MONOTHERAPY ; AGE ; CAPECITABINE ; EFFICACY ; SAFETY ; OLDER
英文摘要

To evaluate the efficacy and safety of gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer (MBC).

Elderly patients with MBC received gemcitabine 1,000 mg m(-2) and vinorelbine 25 mg m(-2) on days 1 and 8 every 3 weeks for a maximum of 6 cycles. The primary end points were objective response and toxicity. The secondary end points included progression-free survival (PFS), overall survival (OS), and prognostic factors associated with disease control, PFS, and OS.

Fifty-one patients with a median age of 73 years (range, 65-84 years) were included. The response rate according to Response Evaluation Criteria in Solid Tumors was 33.3% (95% confidence interval [CI], 20.4 to 46.2%). At a median follow-up of 16.2 months, median PFS and OS were 6.2 (95% CI, 4.6 to 7.8) and 17.0 months (95% CI, 14.5 to 19.5), respectively. Grade 3 to 4 adverse events included neutropenia (25.5%), anemia (13.7%), thrombocytopenia (9.8%), fatigue (5.9%), constipation (3.9%), neuropathy (3.9%), and hepatotoxicity (3.9%). Neutropenic fever occurred in 2 patients. There was one toxic death due to massive gastrointestinal hemorrhage. The study of prognostic factors did not reveal any predictive factor of disease control, while response to treatment and Eastern Cooperative Oncology Group performance status was the main factor conditioning PFS and OS, respectively.

Gemcitabine in combination with vinorelbine is active and safe in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer.

语种英语
WOS记录号WOS:000303418500023
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65165
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Med Oncol Dept,Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Shandong Tumor Hosp & Inst, Dept Chemotherapy, Jinan 250117, Peoples R China
3.Shandong Acad Med Sci, Inst Basic Med, Dept Epidemiol, Jinan 250062, Peoples R China
4.Shandong Tumor Hosp & Inst, Clin Trial Ctr, Jinan 250117, Peoples R China
推荐引用方式
GB/T 7714
Dong, Ningning,Wang, Mingyu,Li, Huiqing,et al. Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY,2012,69(5):1315-1322.
APA Dong, Ningning,Wang, Mingyu,Li, Huiqing,Cui, Yongchun,&Guo, Qisen.(2012).Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer.CANCER CHEMOTHERAPY AND PHARMACOLOGY,69(5),1315-1322.
MLA Dong, Ningning,et al."Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer".CANCER CHEMOTHERAPY AND PHARMACOLOGY 69.5(2012):1315-1322.
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