IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes
Luo, Dali1,2; Yang, Dongmei3; Lan, Xiaomei2; Li, Kaitao4,5; Li, Xiaodong6; Chen, Ju6; Zhang, Youyi2; Xiao, Rui-Ping3,4,5; Han, Qide1,2; Cheng, Heping4,5
关键词cardiomyocytes nuclear Ca2+ signaling inositol 1,4,5-trisphosphate receptors Ca2+ sparks alpha(1) adrenergic stimulation
刊名CELL CALCIUM
2008-02-01
DOI10.1016/j.ceca.2007.04.017
43期:2页:165-174
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]CYTOSOLIC CALCIUM ; CARDIAC MYOCYTES ; TRISPHOSPHATE RECEPTOR ; CYTOPLASMIC CALCIUM ; LIVER NUCLEI ; RELEASE ; EXPRESSION ; CELLS ; RETICULUM ; SIGNAL
英文摘要

Dynamic nuclear Ca2+ signals play pivotal roles in diverse cellular functions including gene transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca2+ regulatory mechanism mediated by mositol 1,4,5-trispliosphate receptors (IP(3)Rs) around the nucleus in developing cardiac myocytes. Activation Of IP(3)Rs by alpha(1)-adrenergic receptor (alpha(1)AR) stimulation or by IP3 application (in saponinpermeabilized cells) increases Ca2+ spark frequency preferentially in the region around the nucleus in neonatal rat ventricular myocytes. A nuclear enrichment Of IP3R distribution supports the higher responsiveness of Ca2+ release in this particular region. Strikingly, we observed "nuclear Ca2+ waves" that engulf the entire nucleus without spreading into the bulk cytosol. alpha(1)AR stimulation enhances the occurrence of nuclear Ca2+ waves and confers them the ability to trigger cytosolic Ca2+ waves via IP3R-dependent pathways. This finding accounts, at least partly, for a profound frequency-dependent modulation of global Ca2+ oscillations during alpha(1) AR stimulation. Thus, IP3R-mediated Ca2+ waves traveling in the nuclear region provide active, autonomous regulation of nuclear Ca2+ signaling, which provides for not only the local signal transduction, but also a pacemaker to drive global Ca2+ transient in the context of alpha(1)AR stimulation in developing cardiac myocytes. (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000254158600006
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被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65166
专题北京大学基础医学院_心血管所
北京大学医学部管理机构_主任办公室党委办公室
作者单位1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China
3.Peking Univ, Inst Cardiovasc Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
4.NIA, Cardiovasc Sci Lab, Baltimore, MD 21224 USA
5.Peking Univ, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
6.Univ Calif San Diego, Inst Mol Med, La Jolla, CA 92093 USA
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GB/T 7714
Luo, Dali,Yang, Dongmei,Lan, Xiaomei,et al. Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes[J]. CELL CALCIUM,2008,43(2):165-174.
APA Luo, Dali.,Yang, Dongmei.,Lan, Xiaomei.,Li, Kaitao.,Li, Xiaodong.,...&Cheng, Heping.(2008).Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes.CELL CALCIUM,43(2),165-174.
MLA Luo, Dali,et al."Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes".CELL CALCIUM 43.2(2008):165-174.
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