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学科主题: 临床医学
题名:
Assessment of pulmonary vasculature volume with automated threshold-based 3D quantitative CT volumetry: In vitro and in vivo validation
作者: Liu, Jingzhe2; Wu, Qingyu1; Xu, Yufeng3; Bai, Yan2; Liu, Zhibo2; Li, Hongyin1; Zhu, Jiemin2
关键词: CT ; Pulmonary arteries ; Software validation
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2012-05-01
DOI: 10.1016/j.ejrad.2011.01.119
卷: 81, 期:5, 页:1040-1044
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: LEFT-VENTRICULAR FUNCTION ; COMPUTED-TOMOGRAPHY ; FONTAN OPERATION ; ARTERY PRESSURES ; BLOOD-FLOW ; HYPERTENSION ; SEGMENTATION ; SIZE ; EMPHYSEMA ; DIAMETER
英文摘要:

Objectives: To validate the ability of threshold-based 3D CT volumetry to enable measurement of volume of visible pulmonary vessels on CT.

Materials and methods: In vivo, 3D CT volumetry was validated in seven phantoms that consisted of silicone tubes embedded in a foam block. With the true volume value as reference standard, the accuracy of CT measurement at various lower thresholds of -600 HU, -500 HU, -300 HU and -200 HU were compared. The volume measurements obtained when filled with varied concentration of iodinated contrast media (1: 100, 1: 200 and 1: 500) were also compared. In vivo validation was performed in sixteen patients (9 men, 7 women; mean age, 52.1 years). Inter-scan and inter-observer agreement and reproducibility for pulmonary vasculature volume measurement were evaluated with Bland-Altman analysis.

Results: In vitro, the mean value measured under lower threshold of -300 HU (relative error = 1.5%) were the closest to the true values and have no significant difference (P = 0.375). There were no significant differences among the phantom measurement values with different filled concentration (1: 100, 1: 200 and 1: 500). In vivo, the inter-scan reproducibility of volume measurements was good, with a correlation coefficient of 0.82 and ICC (intraclass correlation coefficient) of 0.86. Inter-observer agreement was excellent with a correlation coefficient of 0.91 and ICC of 0.95.

Conclusions: The threshold-based 3D quantitative CT volumetry enables accurate and reproducible measurement of pulmonary vessels volume. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 202400008009
项目资助者: Dr. Shun Tak Wu&prime ; s Medical Sciences Fund
WOS记录号: WOS:000303108000053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65167
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Tsinghua Univ, Ctr Heart, Hosp 1, Beijing 100084, Peoples R China
2.Tsinghua Univ, Dept Radiol, Hosp 1, Beijing 100084, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Jingzhe,Wu, Qingyu,Xu, Yufeng,et al. Assessment of pulmonary vasculature volume with automated threshold-based 3D quantitative CT volumetry: In vitro and in vivo validation[J]. EUROPEAN JOURNAL OF RADIOLOGY,2012,81(5):1040-1044.
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