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学科主题: 临床医学
题名:
The prognostic value of peripheral CD4(+)CD25(+) T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion
作者: Song, Qing-Kun1; Ren, Jun1,2,3; Zhou, Xin-Na1,2; Wang, Xiao-Li1,2; Song, Guo-Hong2; Di, Li-Jun2; Yu, Jing2; Hobeika, Amy3; Morse, Michael A.4; Yuan, Yan-Hua1; Yang, Hua-Bing1; Lyerly, Herbert Kim3
关键词: CD4(+)CD25(+) T lymphocyte ; early stage breast cancer ; triple negative breast cancer ; prognosis ; adoptive cell therapy
刊名: ONCOTARGET
发表日期: 2015-12-01
卷: 6, 期:38, 页:41350-41359
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: TUMOR-INFILTRATING LYMPHOCYTES ; PROGRESSION-FREE ; DEPLETION ; SURVIVAL ; IMMUNOTHERAPY ; CHEMOTHERAPY ; EXPRESSION ; IMMUNITY ; TH1
英文摘要:

Objective: This study aimed to assess the prognostic value of CD4(+)CD25(+) T lymphocyte in peripheral blood among breast cancer patients treated with adoptive T lymphocytes immunotherapy.

Methods: 217 patients participated in the follow-up study. CD4(+)CD25(+) proportion was measured by flow cytometry in peripheral T cells. The median survival was estimated by Kaplan-Meier curve, Log-rank test and Cox hazard proportion regression model, between groups of f CD4(+)CD25(+) proportion more than 5% and less than or equal to 5% in peripheral T cells.

Results: Peripheral f CD4(+)CD25(+) T lymphocytes had not a relationship with progression-free survival. It was featured that above 5% peripheral f CD4(+)CD25(+) proportion of T cells was related with the median overall survival by a shorten of 51 months (p < 0.05) with the HR 1.65 (95% CI 1.04, 2.62). Above 5% f CD4(+)CD25(+) proportion of T cells produced the HR to be 1.76 (95% CI 1.07, 2.87) In stage 0-II patients, and 3.59 (95% CI 1.05, 12.29) in triple negative breast cancer patients.

Conclusion: Cellular immunity restoration recovered by adoptive T cell infusions which resulted in less proportion of peripheral f CD4(+)CD25(+) T lymphocytes could be a potential prognostic indicator among early stage and triple negative patients.

语种: 英语
所属项目编号: 2013 ZLNK ; 2013 ZLYJS ; XMLX201413 ; 81172534
项目资助者: collaborative research project of Duke University Medical Center, Durham, NC, US ; Capital Medical University Cancer Center, Beijing, China ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Natural Science Foundation of China
WOS记录号: WOS:000366115500072
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65171
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Duke Univ, Dept Surg, Med Ctr, Durham, NC 27710 USA
2.Duke Univ, Dept Med, Med Ctr, Durham, NC 27710 USA
3.Capital Med Univ, Ctr Canc, Beijing Shijitan Hosp, Beijing Key Lab Therapeut Canc Vaccines, Beijing 10038, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Med Oncol, Beijing 100142, Peoples R China

Recommended Citation:
Song, Qing-Kun,Ren, Jun,Zhou, Xin-Na,et al. The prognostic value of peripheral CD4(+)CD25(+) T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion[J]. ONCOTARGET,2015,6(38):41350-41359.
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