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学科主题临床医学
Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats
Liang, Yaoxian1; Li, Zhengqian2; Mo, Na3; Li, Min2; Zhuang, Zhen1; Wang, Jun2; Wang, Yue1; Guo, Xiangyang2
关键词acute kidney injury ischemia-reperfusion volatile anesthetic inflammation apoptosis
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2014-10-01
37期:10页:1599-1605
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ACUTE KIDNEY INJURY ; AGED RATS ; HMGB1 ; APOPTOSIS ; PROTECTS ; INFLAMMATION ; PATHWAY ; MICE ; ACTIVATION ; EXPRESSION
英文摘要

Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury via inflammation and cell apoptosis. Volatile anesthetics have been shown to exert organ-protective effects against kidney damage in vivo and in vitro. In the present study, we investigated the effects of isoflurane, a commonly used volatile anesthetic, on renal I/R injury and the underlying mechanisms. Rats subjected to renal I/R displayed higher serum creatinine and blood urea nitrogen levels than sham rats as well as severe histopathological damage. Renal I/R also resulted in a nuclear factor-kappa B (NF-kappa B)-mediated inflammatory response and dysfunction of the p53-Bax-caspase-3 apoptotic pathway. Rats preconditioned with 1.5% isoflurane for 2 h had better renal function and less tubular apoptosis 24h after I/R injury than control rats. Pretreatment with isoflurane suppressed renal NF-kappa B activation, leading to a reduction in proinflammatory molecules (high-mobility group box 1, interleukin-1 beta, and tumor necrosis factor-alpha) both in the kidneys and circulation. In addition, rats subjected to isoflurane preconditioning had a higher Bcl-2/Bax ratio and less cleaved caspase-3. Our findings suggest that preconditioning with a clinically relevant concentration of isoflurane attenuates renal I/R injury, based at least in part on its ability to modulate renal inflammation and apoptosis.

语种英语
WOS记录号WOS:000342479800004
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65174
专题北京大学第三临床医学院_肾内科
北京大学第一临床医学院_耳鼻咽喉头颈外科
北京大学第二临床医学院_肾内科
北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Canc Inst & Hosp, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Liang, Yaoxian,Li, Zhengqian,Mo, Na,et al. Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2014,37(10):1599-1605.
APA Liang, Yaoxian.,Li, Zhengqian.,Mo, Na.,Li, Min.,Zhuang, Zhen.,...&Guo, Xiangyang.(2014).Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats.BIOLOGICAL & PHARMACEUTICAL BULLETIN,37(10),1599-1605.
MLA Liang, Yaoxian,et al."Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats".BIOLOGICAL & PHARMACEUTICAL BULLETIN 37.10(2014):1599-1605.
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