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学科主题: 临床医学
题名:
Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats
作者: Liang, Yaoxian1; Li, Zhengqian2; Mo, Na3; Li, Min2; Zhuang, Zhen1; Wang, Jun2; Wang, Yue1; Guo, Xiangyang2
关键词: acute kidney injury ; ischemia-reperfusion ; volatile anesthetic ; inflammation ; apoptosis
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2014-10-01
卷: 37, 期:10, 页:1599-1605
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ACUTE KIDNEY INJURY ; AGED RATS ; HMGB1 ; APOPTOSIS ; PROTECTS ; INFLAMMATION ; PATHWAY ; MICE ; ACTIVATION ; EXPRESSION
英文摘要:

Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury via inflammation and cell apoptosis. Volatile anesthetics have been shown to exert organ-protective effects against kidney damage in vivo and in vitro. In the present study, we investigated the effects of isoflurane, a commonly used volatile anesthetic, on renal I/R injury and the underlying mechanisms. Rats subjected to renal I/R displayed higher serum creatinine and blood urea nitrogen levels than sham rats as well as severe histopathological damage. Renal I/R also resulted in a nuclear factor-kappa B (NF-kappa B)-mediated inflammatory response and dysfunction of the p53-Bax-caspase-3 apoptotic pathway. Rats preconditioned with 1.5% isoflurane for 2 h had better renal function and less tubular apoptosis 24h after I/R injury than control rats. Pretreatment with isoflurane suppressed renal NF-kappa B activation, leading to a reduction in proinflammatory molecules (high-mobility group box 1, interleukin-1 beta, and tumor necrosis factor-alpha) both in the kidneys and circulation. In addition, rats subjected to isoflurane preconditioning had a higher Bcl-2/Bax ratio and less cleaved caspase-3. Our findings suggest that preconditioning with a clinically relevant concentration of isoflurane attenuates renal I/R injury, based at least in part on its ability to modulate renal inflammation and apoptosis.

语种: 英语
所属项目编号: 81371205 ; 81070213 ; 20110001110008
项目资助者: National Natural Science Foundation of China ; Ministry of Education of China
WOS记录号: WOS:000342479800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65174
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Canc Inst & Hosp, Beijing 100021, Peoples R China

Recommended Citation:
Liang, Yaoxian,Li, Zhengqian,Mo, Na,et al. Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2014,37(10):1599-1605.
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