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学科主题: 临床医学
题名:
Inflammatory responses after intracoronary mononuclear BM cell therapy in swine
作者: Xu, S.; Xu, X.; Guo, Y.; Gao, W.1
关键词: mononuclear bone marrow cells ; cell therapy ; cytokines ; ventricular function ; swine
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2009-10-01
DOI: 10.1038/bmt.2009.52
卷: 44, 期:7, 页:427-431
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; HEMATOPOIETIC STEM-CELLS ; CORONARY-ARTERY-DISEASE ; BONE-MARROW-CELLS ; CYTOKINES ; TRANSPLANTATION ; TRIAL
英文摘要:

The aim of this study was to investigate the influence of intracoronary injection of mononuclear BM cells (mBMCs) on inflammatory mediators in swine with acute myocardial infarction (AMI) in two groups. Group 1 received the therapy immediately after AMI, but group 2 received it after 3 weeks. The levels of cytokines and heart functions, respectively, were examined 3 weeks after cell therapy. The serum levels of TNF-alpha and IL-8 were significantly lower than in the control group: in contrast, IL-10 was significantly elevated in the cell recipients, especially in group 1. TNF-alpha correlated with IL-8 between groups. The ventricular functions were significantly improved. These results show that although the intracoronary injection of mBMCs induces a marked short-term inflammatory response in the acute stage, mBMCs may play an anti-inflammatory role topically and systematically and early cell therapy may be preferable. Bone Marrow Transplantation (2009) 44, 427-431; doi: 10.1038/bmt.2009.52; published online 30 March 2009

语种: 英语
所属项目编号: 2004BA714B-1
项目资助者: National Science Project
WOS记录号: WOS:000270933000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65179
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Xu, S.,Xu, X.,Guo, Y.,et al. Inflammatory responses after intracoronary mononuclear BM cell therapy in swine[J]. BONE MARROW TRANSPLANTATION,2009,44(7):427-431.
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