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学科主题临床医学
Inflammatory responses after intracoronary mononuclear BM cell therapy in swine
Xu, S.; Xu, X.; Guo, Y.; Gao, W.1
关键词mononuclear bone marrow cells cell therapy cytokines ventricular function swine
刊名BONE MARROW TRANSPLANTATION
2009-10-01
DOI10.1038/bmt.2009.52
44期:7页:427-431
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
资助者National Science Project ; National Science Project
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; HEMATOPOIETIC STEM-CELLS ; CORONARY-ARTERY-DISEASE ; BONE-MARROW-CELLS ; CYTOKINES ; TRANSPLANTATION ; TRIAL
英文摘要

The aim of this study was to investigate the influence of intracoronary injection of mononuclear BM cells (mBMCs) on inflammatory mediators in swine with acute myocardial infarction (AMI) in two groups. Group 1 received the therapy immediately after AMI, but group 2 received it after 3 weeks. The levels of cytokines and heart functions, respectively, were examined 3 weeks after cell therapy. The serum levels of TNF-alpha and IL-8 were significantly lower than in the control group: in contrast, IL-10 was significantly elevated in the cell recipients, especially in group 1. TNF-alpha correlated with IL-8 between groups. The ventricular functions were significantly improved. These results show that although the intracoronary injection of mBMCs induces a marked short-term inflammatory response in the acute stage, mBMCs may play an anti-inflammatory role topically and systematically and early cell therapy may be preferable. Bone Marrow Transplantation (2009) 44, 427-431; doi: 10.1038/bmt.2009.52; published online 30 March 2009

语种英语
所属项目编号2004BA714B-1
资助者National Science Project ; National Science Project
WOS记录号WOS:000270933000004
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65179
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, S.,Xu, X.,Guo, Y.,et al. Inflammatory responses after intracoronary mononuclear BM cell therapy in swine[J]. BONE MARROW TRANSPLANTATION,2009,44(7):427-431.
APA Xu, S.,Xu, X.,Guo, Y.,&Gao, W..(2009).Inflammatory responses after intracoronary mononuclear BM cell therapy in swine.BONE MARROW TRANSPLANTATION,44(7),427-431.
MLA Xu, S.,et al."Inflammatory responses after intracoronary mononuclear BM cell therapy in swine".BONE MARROW TRANSPLANTATION 44.7(2009):427-431.
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