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学科主题基础医学
Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection
Yu, Yan-Rong1; Deng, Ming-Jun2; Lu, Wei-Wei1; Zhang, Jin-Sheng1; Jia, Mo-Zhi1; Huang, Jie1; Qi, Yong-Fen1,3
关键词Trichinella spiralis Apoptosis Endoplasmic reticulum stress Gastrointestinal helminth
刊名EXPERIMENTAL PARASITOLOGY
2014-10-01
DOI10.1016/j.exppara.2014.06.017
145页:1-6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Parasitology
资助者National Quality Inspection Public Welfare Scientific Research Project ; National Natural Science Foundation of China ; Leading Academic Discipline Project of Beijing Education Bureau ; National Quality Inspection Public Welfare Scientific Research Project ; National Natural Science Foundation of China ; Leading Academic Discipline Project of Beijing Education Bureau
研究领域[WOS]Parasitology
关键词[WOS]POSTINFECTIOUS GUT DYSFUNCTION ; UNFOLDED PROTEIN RESPONSE ; ER STRESS ; NEMATODE INFECTION ; RAT ; PROTECTION
英文摘要

Gastrointestinal helminth infection, including Trichinella spiralis, initiates a series of intestinal structural, cellular and physiological changes. Intestinal invasion is an important stage of trichinellosis because it determines the development and subsequent course of the disease and its consequences. Apoptosis mediated by endoplasmic reticulum stress (ERS) plays a key role in infectious diseases, but the effect of T. spiralis infection on inducing apoptosis in the small intestine has been neglected. We investigated apoptosis and changes in ERS-associated apoptosis molecules in the intestine of mice with T. spiralis infection. TUNEL staining and detection of the apoptotic marker cleaved caspase 3 revealed that apoptosis occurred in the mouse intestine at days 3 and 7 post-infection. The ER chaperone 78-kDa glucose-regulated protein (GRP78) was upregulated at days 3 and 7 post-infection. The ERS-associated apoptosis molecules C/EBP homologous protein, cleaved caspase 12 and c-Jun NH2-terminal kinase were upregulated at days 3 and 7, days 3, 7 and 10 and days 7 and 10 post-infection, respectively. Thus, apoptosis occurred in the intestine of mice with T. spiralis infection, and the ERS-mediated apoptosis pathway was activated by infection with this small intestine dwelling nematode. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
所属项目编号201110039 ; 30901247
资助者National Quality Inspection Public Welfare Scientific Research Project ; National Natural Science Foundation of China ; Leading Academic Discipline Project of Beijing Education Bureau ; National Quality Inspection Public Welfare Scientific Research Project ; National Natural Science Foundation of China ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号WOS:000342654800001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65181
专题北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathogen Biol, Beijing 100191, Peoples R China
2.Entry Exit Inspect & Quarantine Bur, Tech Ctr Shandong, Qingdao 266002, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Bioact Mol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yu, Yan-Rong,Deng, Ming-Jun,Lu, Wei-Wei,et al. Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection[J]. EXPERIMENTAL PARASITOLOGY,2014,145:1-6.
APA Yu, Yan-Rong.,Deng, Ming-Jun.,Lu, Wei-Wei.,Zhang, Jin-Sheng.,Jia, Mo-Zhi.,...&Qi, Yong-Fen.(2014).Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection.EXPERIMENTAL PARASITOLOGY,145,1-6.
MLA Yu, Yan-Rong,et al."Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection".EXPERIMENTAL PARASITOLOGY 145(2014):1-6.
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