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学科主题: 基础医学
题名:
Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection
作者: Yu, Yan-Rong1; Deng, Ming-Jun2; Lu, Wei-Wei1; Zhang, Jin-Sheng1; Jia, Mo-Zhi1; Huang, Jie1; Qi, Yong-Fen1,3
关键词: Trichinella spiralis ; Apoptosis ; Endoplasmic reticulum stress ; Gastrointestinal helminth
刊名: EXPERIMENTAL PARASITOLOGY
发表日期: 2014-10-01
DOI: 10.1016/j.exppara.2014.06.017
卷: 145, 页:1-6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Parasitology
研究领域[WOS]: Parasitology
关键词[WOS]: POSTINFECTIOUS GUT DYSFUNCTION ; UNFOLDED PROTEIN RESPONSE ; ER STRESS ; NEMATODE INFECTION ; RAT ; PROTECTION
英文摘要:

Gastrointestinal helminth infection, including Trichinella spiralis, initiates a series of intestinal structural, cellular and physiological changes. Intestinal invasion is an important stage of trichinellosis because it determines the development and subsequent course of the disease and its consequences. Apoptosis mediated by endoplasmic reticulum stress (ERS) plays a key role in infectious diseases, but the effect of T. spiralis infection on inducing apoptosis in the small intestine has been neglected. We investigated apoptosis and changes in ERS-associated apoptosis molecules in the intestine of mice with T. spiralis infection. TUNEL staining and detection of the apoptotic marker cleaved caspase 3 revealed that apoptosis occurred in the mouse intestine at days 3 and 7 post-infection. The ER chaperone 78-kDa glucose-regulated protein (GRP78) was upregulated at days 3 and 7 post-infection. The ERS-associated apoptosis molecules C/EBP homologous protein, cleaved caspase 12 and c-Jun NH2-terminal kinase were upregulated at days 3 and 7, days 3, 7 and 10 and days 7 and 10 post-infection, respectively. Thus, apoptosis occurred in the intestine of mice with T. spiralis infection, and the ERS-mediated apoptosis pathway was activated by infection with this small intestine dwelling nematode. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 201110039 ; 30901247
项目资助者: National Quality Inspection Public Welfare Scientific Research Project ; National Natural Science Foundation of China ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号: WOS:000342654800001
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65181
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathogen Biol, Beijing 100191, Peoples R China
2.Entry Exit Inspect & Quarantine Bur, Tech Ctr Shandong, Qingdao 266002, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Bioact Mol, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Yan-Rong,Deng, Ming-Jun,Lu, Wei-Wei,et al. Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection[J]. EXPERIMENTAL PARASITOLOGY,2014,145:1-6.
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