IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Susceptibility and Diversity in the Therapy-Refractory Genus Scedosporium
Lackner, M.1; Hagen, F.2; Meis, J. F.2,3; van den Ende, A. H. G. Gerrits4; Vu, D.4; Robert, V.4; Fritz, J.5; Moussa, T. A. A.6,7; de Hoog, G. S.4,7,8,9,10,11,12
刊名ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2014-10-01
DOI10.1128/AAC.03211-14
58期:10页:5877-5885
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Microbiology ; Pharmacology & Pharmacy
关键词[WOS]CYSTIC-FIBROSIS PATIENTS ; PSEUDALLESCHERIA-BOYDII ; IN-VITRO ; ANTIFUNGAL SUSCEPTIBILITY ; AMPHOTERICIN-B ; APIOSPERMUM ; VORICONAZOLE ; PROLIFICANS ; AGENT ; SPP.
英文摘要

Scedosporium species show decreased susceptibility to the majority of systemic antifungal drugs. Acquired resistance is likely to disseminate differentially with the mode of exchange of genetic material between lineages. Inter-and intraspecific diversities of Scedosporium species were analyzed for three partitions (rDNA internal transcribed spacer gene [ITS], partial beta-tubulin gene, and amplified fragment length polymorphism profiles), with the aim to establish distribution of resistance between species, populations, and strains. Heterogeneity of and recombination between lineages were determined, and distances between clusters were calculated using a centroid approach. Clinical, geographic, and antifungal data were plotted on diversity networks. Scedosporium minutisporum, Scedosporium desertorum, and Scedosporium aurantiacum were distinguished unambiguously in all partitions and had differential antifungal susceptibility profiles (ASP). Pseudallescheria fusoidea and Pseudallescheria ellipsoidea were indistinguishable from Scedosporium boydii. Pseudallescheria angusta took an intermediate position between Scedosporium apiospermum and S. boydii. Scedosporium boydii and S. apiospermum had identical ASP. Differences in (multi)resistance were linked to individual strains. S. apiospermum and S. boydii showed limited interbreeding and were recognized as valid, sympatric species. The S. apiospermum/S. boydii group, comprising the main clinically relevant Scedosporium species, consists of separate lineages and is interpreted as a complex undergoing sympatric evolution with incomplete lineage sorting. In routine diagnostics, the lineages in S. apiospermum/S. boydii are indicated with the umbrella descriptor "S. apiospermum complex"; individual species can be identified with rDNA ITS with 96.3% confidence. Voriconazole is recommended as the first-line treatment; resistance against this compound is rare.

语种英语
WOS记录号WOS:000344157500029
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65182
Collection北京大学第一临床医学院_皮肤性病科
作者单位1.Med Univ Innsbruck, Div Hyg & Med Microbiol, A-6020 Innsbruck, Austria
2.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
3.Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
4.Med Univ Innsbruck, Dept Med Stat Informat & Hlth Econ, A-6020 Innsbruck, Austria
5.King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Jeddah, Saudi Arabia
6.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
7.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
10.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil
11.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
12.Cairo Univ, Fac Sci, Dept Bot & Microbiol, Giza, Egypt
Recommended Citation
GB/T 7714
Lackner, M.,Hagen, F.,Meis, J. F.,et al. Susceptibility and Diversity in the Therapy-Refractory Genus Scedosporium[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2014,58(10):5877-5885.
APA Lackner, M..,Hagen, F..,Meis, J. F..,van den Ende, A. H. G. Gerrits.,Vu, D..,...&de Hoog, G. S..(2014).Susceptibility and Diversity in the Therapy-Refractory Genus Scedosporium.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,58(10),5877-5885.
MLA Lackner, M.,et al."Susceptibility and Diversity in the Therapy-Refractory Genus Scedosporium".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 58.10(2014):5877-5885.
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