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学科主题: 临床医学
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To be or not to be: Significance of lymph nodes on pretreatment CT in predicting survival of rectal cancer patients
作者: Chi, Yong-Kun; Zhang, Xiao-Peng; Li, Jie; Sun, Ying-Shi
关键词: Rectal cancer ; Lymph node ; CT ; Survival
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2011-03-01
DOI: 10.1016/j.ejrad.2009.09.016
卷: 77, 期:3, 页:473-477
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: COLORECTAL-CANCER ; PROGNOSTIC-FACTORS ; COLON-CANCER ; CARCINOMA ; ACCURACY ; RESECTION ; STAGE ; DUKES ; NUMBER
英文摘要:

Purpose: To assess the extent to which pretreatment imaging of lymph nodes by computed tomography (CT) predicts survival of patients with rectal cancer.

Materials and methods: We retrospectively analyzed 70 patients with rectal cancer, who had pretreatment CT and curative surgery between December 1999 and October 2003. These patients were followed until December 2007, ensuring minimal follow-up time of 49 months. Two radiologists who reviewed the CT images on workstations had no prior access to clinical and treatment information regarding the selected patients. The parameters assessed for survival analysis were as follows: patient age, sex, CEA and CA199 level, preoperational therapy, tumor location, serosal invasion, largest diameters and numbers of lymph nodes on pretreatment CT. Kaplan-Meier survival curves, the log-rank test, and the multivariate Cox proportional hazards model were used to evaluate the prognostic value of the parameters.

Results: Using pretreatment CT as prognostic tool, we found that both size and number of lymph nodes correlated with the overall survival of patients with rectal cancer. The data proved that a diameter smaller than 8 mm for the largest lymph node was correlated with prolonged survival (P < 0.001). Meanwhile, patients with more than 4 lymph nodes had a significantly worse disease-specific survival (P = 0.042). Both parameters are independent prognostic factors (hazard ratio 4.910 and 3.563) and could predict the overall survival of rectal cancer patients.

Conclusion: The lymph node size and number, as determined by pretreatment CT, is an important clinical prognostic factor in patients with rectal cancer. The pretreatment CT findings could be used to predict survival and plan appropriate therapies. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006CB705706 ; 2007-3081
项目资助者: National Basic Research Program of China (973 Program) ; Capital Medical Development Research Fund
WOS记录号: WOS:000288247100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65184
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Radiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Chi, Yong-Kun,Zhang, Xiao-Peng,Li, Jie,et al. To be or not to be: Significance of lymph nodes on pretreatment CT in predicting survival of rectal cancer patients[J]. EUROPEAN JOURNAL OF RADIOLOGY,2011,77(3):473-477.
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