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The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage
Yu, Yao1; Zhao, Wei2; Zhu, Chunpeng2; Kong, Zhiping2; Xu, Yan1; Liu, Guangzhi1; Gao, Xuguang1
刊名PLOS ONE
2015-04-13
DOI10.1371/journal.pone.0122371
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BRAIN-INJURY ; PERIHEMATOMAL EDEMA ; AGED RATS ; IRON ACCUMULATION ; NATURAL-HISTORY ; NEURONAL DEATH ; CASE-FATALITY ; STROKE ; MODEL ; TRIAL
英文摘要

Background and Purpose

It has been shown that 3 days of 62 mg/kg/day deferoxamine infusion (maximum dose not to exceed 6000 mg/day) is safe and tolerated by intracerebral hemorrhage (ICH) patients. The aim of this study was to investigate the efficacy of deferoxamine mesylate for edema resolution and hematoma absorption after ICH.

Methods

From February 2013 to May 2014, spontaneous ICH patients diagnosed by computed tomography (CT) within 18 hours of onset were evaluated. Patients were randomly divided into two groups: an experimental group and a control group. The treatment of the two groups was similar except that the experimental group received deferoxamine mesylate. Patients were evaluated by CT and neurology scale at the time of admission, and on the fourth, eighth, and fifteenth day (or at discharge) after admission. Patients were followed up for the first 30 days and clinical data of the two groups were compared.

Results

Forty-two patients completed 30 days of follow-up by May 2014; 21 cases in the experimental group and 21 cases in the control group. The control group′s relative edema volume on the fifteenth day (or discharge) was 10.26 +/- 17.54, which was higher than the experimental group (1.91 +/- 1.94; P < 0.05). The control group′s 1-8 day and 8-15 day relative hematoma absorption were greater than the experimental group (P < 0.05). The control group′s relative edema volume on the fourth, eighth, and fifteenth day (or discharge) was higher than the experimental group (P < 0.05). Neurological scores between the two groups were not statistically different on the fifteenth day (or discharge) or on the thirtieth day.

Conclusions

Deferoxamine mesylate may slow hematoma absorption and inhibit edema after ICH, although further investigation is required to form definitive conclusions.

语种英语
WOS记录号WOS:000352845100068
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65193
专题北京大学第二临床医学院_神经内科
作者单位1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100871, Peoples R China
2.Mancheng Country Hosp, Dept Internal Med, Baoding, Peoples R China
推荐引用方式
GB/T 7714
Yu, Yao,Zhao, Wei,Zhu, Chunpeng,et al. The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage[J]. PLOS ONE,2015,10(4).
APA Yu, Yao.,Zhao, Wei.,Zhu, Chunpeng.,Kong, Zhiping.,Xu, Yan.,...&Gao, Xuguang.(2015).The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage.PLOS ONE,10(4).
MLA Yu, Yao,et al."The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage".PLOS ONE 10.4(2015).
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