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学科主题: 药学
题名:
Analysis on the stability of total phenolic acids and salvianolic acid B from Salvia miltiorrhiza by HPLC and HPLC-MS(n)
作者: Xu, Man; Han, Jian; Li, Hui-feng; Fan, Li; Liu, Ai-hua; Guo, De-an
关键词: Salvia miltiorrhiza ; total phenolic acids ; salvianolic acid B ; stability ; degradation products ; LC-MS(n)
刊名: NATURAL PRODUCT COMMUNICATIONS
发表日期: 2008
卷: 3, 期:5, 页:669-676
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Food Science & Technology
研究领域[WOS]: Pharmacology & Pharmacy ; Food Science & Technology
关键词[WOS]: IONIZATION MASS-SPECTROMETRY ; MAGNESIUM LITHOSPERMATE-B ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; DAD-ESI-MSN ; DANSHEN ; ROOTS ; CELLS ; FLAVONOIDS ; RATS
英文摘要:

The stability of salvianolic acid B and total phenolic acids from Salvia miltiorrhiza in water solutions at different temperatures, in buffered aqueous solutions at different pHs and in biological fluids, including simulated gastric and intestinal fluids, were investigated in vitro. The results showed that the degradation of salvianolic acid B was pH- and temperature-dependent. Furthermore, structures of the degradation products of salvianolic acid B and total phenolic acids were elucidated by liquid chromatography-electrospray ion trap mass spectrometry and analysis of the degraded solutions revealed seventeen degradation products. The possible degradation pathway of salvianolic acid B is proposed.

语种: 英语
WOS记录号: WOS:000256280100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65194
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Man,Han, Jian,Li, Hui-feng,et al. Analysis on the stability of total phenolic acids and salvianolic acid B from Salvia miltiorrhiza by HPLC and HPLC-MS(n)[J]. NATURAL PRODUCT COMMUNICATIONS,2008,3(5):669-676.
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