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学科主题: 精神卫生
题名:
Susceptibility genes, social environmental risk factors and their interactions in internalizing disorders among mainland Chinese undergraduates
作者: Meng, Xiangfei1,2; Kou, Changgui1; Shi, Jieping1; Yu, Yaqin1; Huang, Yueqin3
关键词: Internalizing disorder ; Gene x environment interaction ; Gene x gene interaction ; Brain-derived neurotrophic factor (BDNF) ; Monoamine oxidase (MAOA) ; 5-hydroxytryptamine transporter (SLC6A4) ; Tag SNP
刊名: JOURNAL OF AFFECTIVE DISORDERS
发表日期: 2011-07-01
DOI: 10.1016/j.jad.2011.01.005
卷: 132, 期:1-2, 页:254-259
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: SEROTONIN TRANSPORTER POLYMORPHISM ; COMMON MENTAL-DISORDERS ; STRESSFUL LIFE EVENTS ; PSYCHIATRIC-DISORDERS ; DSM-IV ; DEPRESSION ; ANXIETY ; PSYCHOPATHOLOGY ; BDNF ; REPLICATION
英文摘要:

Background: Analyses of large scale psychiatric epidemiology surveys suggest that common mental disorders can be generalized into two underlying dimensions, internalizing disorders (e.g. depression, and anxiety) and externalizing disorders (e.g. addictions). The present study explores the interactions among the genes (SLC6A4, BDNF, and MAOA) and selected environment factors (G x E), and gene x gene (G x G) interactions for internalizing disorders in the sample of Chinese university students.

Methods: This is a genetic case control study. 259 undergraduates affected with internalizing disorders and 269 healthy controls were included. Multiple logistic regression was used to explore the potential environmental risk factors. G x E interactions were analyzed using the method developed by Mukherjee et al. (2008). Analyses of G x G interactions were conducted by generalized multifactor dimensionality reduction (GMDR) (Lou et al., 2007). We have previously reported on the polymorphism information for ten single nucleotide polymorphisms (SNPs) on SLC6A4, BDNF, and MAOA genes (Meng et al., 2009; Meng, 2010).

Results: We found that an offspring′s reported parents′ negative mood, subject′s unwillingness to express emotion, being an only child, having an unfulfilling relationship with his/her mother, and increased activity and behavior restrictions by his/her father were social environment risk factors for internalizing disorders. No statistically significant interactions were found in the G x E analyses. G x G analyses found that subjects with mutational alleles concurrently on rs10835210 and rs2030324 (BDNF gene) were significantly likely to develop internalizing disorders. Those with one mutated allele on either SNPs were 1.761 times, and those with both mutated alleles were 3.353 times, more likely to develop internalizing disorders.

Conclusion: A negative family emotional environment was found to be associated with internalizing disorders. BDNF gene variants were also found to be similarly associated. Using conservative statistical analyses we did not find any G x E interactions. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30972536
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000292438400033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65196
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Saskatchewan, Coll Med, Saskatoon, SK S7N 0W8, Canada
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Jilin Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Ctr Med Genom, Changchun 130021, Peoples R China

Recommended Citation:
Meng, Xiangfei,Kou, Changgui,Shi, Jieping,et al. Susceptibility genes, social environmental risk factors and their interactions in internalizing disorders among mainland Chinese undergraduates[J]. JOURNAL OF AFFECTIVE DISORDERS,2011,132(1-2):254-259.
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