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Prescribing antipsychotic drugs for inpatients with schizophrenia in Asia: Comparison of REAP-2001 and REAP-2004 studies
Chong, Mian-Yoon1,2; Tan, Chay Hoon3; Shinfuku, Naotaka4; Yang, Shu-Yu5; Sim, Kang6; Fujii, Senta7; Si, Tianmei8; Chung, Eun Kee9; Kua, Ee Heok10
关键词antipsychotic prescription antipsychotic utilization inpatient schizophrenia treatment pharmacoepidemiology
刊名ASIA-PACIFIC PSYCHIATRY
2010-06-01
DOI10.1111/j.1758-5872.2010.00068.x
2期:2页:77-84
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]EAST-ASIA ; PATTERNS ; PRESCRIPTION ; POLYPHARMACY
英文摘要

Introduction

This international collaborative study aimed to investigate the trend and change in prescription patterns of antipsychotic drugs for inpatient schizophrenia in Asia by comparing two surveys in 2001 and 2004.

Methods

Prescription patterns of inpatient schizophrenia in China, Hong Kong, Japan, Korea, Singapore and Taiwan were surveyed in July of 2001 and 2004 using a standardized protocol. Patients′ social and clinical characteristics, psychiatric symptoms, course of illness and adverse effects of medications were systematically assessed and recorded. Prescription patterns of antipsychotic drugs were compared and analyzed.

Results

Altogether, 4535 patients were surveyed. There were no significant differences in their demographic characteristics between 2001 and 2004. Compared with 2001, a significant increase in the use of second-generation antipsychotics (SGA) (from 45.5% to 64.7%) with reciprocal decreasing use of first-generation antipsychotics was found in 2004. The trend was unanimously seen across these Asian countries and among those prescribed with monotherapy or polypharmacy. The proportion using monotherapy significantly increased, from 52.7% in 2001 to 61.1% in 2004. There was a tendency of using a lower dosage of antipsychotic medications and a less concomitant use of anti-Parkinson drugs.

Discussion

The present study showed a trend of increasing use of SGA among Asian countries. Except for Japan and Singapore, a relatively low use of antipsychotic polypharmacy was generally found. The increasing use of SGA and policy changes reduced the mean duration of admission days. With increasing awareness of consumers and continuing education for psychiatrists, the trend is expected to continue.

语种英语
WOS记录号WOS:000278075100004
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65197
专题北京大学精神卫生研究所
作者单位1.Hyogo Inst Traumat Stress, Res Dept, Kobe, Hyogo, Japan
2.Seoul Natl Mental Hosp, Seoul, South Korea
3.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung Med Ctr, Kaohsiung 83301, Taiwan
4.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore
5.Beijing Med Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
6.Natl Univ Singapore, Dept Psychiat, Singapore 117548, Singapore
7.Chang Gung Univ, Sch Med, Kaohsiung 83301, Taiwan
8.Seinan Gakui Univ, Sch Human Sci, Fuokuoka, Japan
9.Taipei City Hosp, Dept Pharm, Taipei, Taiwan
10.Woodbridge Hosp, Inst Mental Hlth, Singapore, Singapore
推荐引用方式
GB/T 7714
Chong, Mian-Yoon,Tan, Chay Hoon,Shinfuku, Naotaka,et al. Prescribing antipsychotic drugs for inpatients with schizophrenia in Asia: Comparison of REAP-2001 and REAP-2004 studies[J]. ASIA-PACIFIC PSYCHIATRY,2010,2(2):77-84.
APA Chong, Mian-Yoon.,Tan, Chay Hoon.,Shinfuku, Naotaka.,Yang, Shu-Yu.,Sim, Kang.,...&Kua, Ee Heok.(2010).Prescribing antipsychotic drugs for inpatients with schizophrenia in Asia: Comparison of REAP-2001 and REAP-2004 studies.ASIA-PACIFIC PSYCHIATRY,2(2),77-84.
MLA Chong, Mian-Yoon,et al."Prescribing antipsychotic drugs for inpatients with schizophrenia in Asia: Comparison of REAP-2001 and REAP-2004 studies".ASIA-PACIFIC PSYCHIATRY 2.2(2010):77-84.
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