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学科主题: 药学
题名:
Microbial hydroxylation of cinobufagin by Mucor spinosus
作者: Zhang, W; Ye, M; Qu, GQ; Wu, WY; Chen, YJ; Guo, DA
关键词: biotransformation ; cinobufagin ; Mucor spinosus
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2005-06-01
DOI: 10.1080/10286020410001690136
卷: 7, 期:3, 页:225-229
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CELL-SUSPENSION CULTURES ; CATHARANTHUS-ROSEUS ; ASPERGILLUS-NIGER ; BIOTRANSFORMATION ; BUFADIENOLIDES ; 11-TAXADIENE ; ARTEMISININ ; PLANT
英文摘要:

Mucor spinosus has been employed for the biotransformation of cinobufagin ( 1 ) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1beta-hydroxy-cinobufagin ( 2 ), 12beta-hydroxy-cinobufagin ( 3 ) and 1beta,12beta-dihydroxy-cinobufagin ( 4 ), of which metabolites 2 and 4 are new compounds. In vitro cytotoxic activities of the biotransformation products and the substrate-cinobufagin have been assayed against four tumor cell lines of Bel 7420, BGC 823, HeLa and HL 60; they all showed cytotoxic activities.

语种: 英语
WOS记录号: WOS:000226204700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65201
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Shenyang Phrmaceut Univ, Shenyang, Liaoning, Peoples R China

Recommended Citation:
Zhang, W,Ye, M,Qu, GQ,et al. Microbial hydroxylation of cinobufagin by Mucor spinosus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2005,7(3):225-229.
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