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Microbial hydroxylation of cinobufagin by Mucor spinosus
Zhang, W; Ye, M; Qu, GQ; Wu, WY; Chen, YJ; Guo, DA
关键词biotransformation cinobufagin Mucor spinosus
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2005-06-01
DOI10.1080/10286020410001690136
7期:3页:225-229
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CELL-SUSPENSION CULTURES ; CATHARANTHUS-ROSEUS ; ASPERGILLUS-NIGER ; BIOTRANSFORMATION ; BUFADIENOLIDES ; 11-TAXADIENE ; ARTEMISININ ; PLANT
英文摘要

Mucor spinosus has been employed for the biotransformation of cinobufagin ( 1 ) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1beta-hydroxy-cinobufagin ( 2 ), 12beta-hydroxy-cinobufagin ( 3 ) and 1beta,12beta-dihydroxy-cinobufagin ( 4 ), of which metabolites 2 and 4 are new compounds. In vitro cytotoxic activities of the biotransformation products and the substrate-cinobufagin have been assayed against four tumor cell lines of Bel 7420, BGC 823, HeLa and HL 60; they all showed cytotoxic activities.

语种英语
WOS记录号WOS:000226204700005
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65201
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Shenyang Phrmaceut Univ, Shenyang, Liaoning, Peoples R China
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Zhang, W,Ye, M,Qu, GQ,et al. Microbial hydroxylation of cinobufagin by Mucor spinosus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2005,7(3):225-229.
APA Zhang, W,Ye, M,Qu, GQ,Wu, WY,Chen, YJ,&Guo, DA.(2005).Microbial hydroxylation of cinobufagin by Mucor spinosus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,7(3),225-229.
MLA Zhang, W,et al."Microbial hydroxylation of cinobufagin by Mucor spinosus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 7.3(2005):225-229.
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