|Characteristics of Sjogren′s syndrome in rheumatoid arthritis|
|He, Jing1; Ding, Yan1; Feng, Min1; Guo, Jianping1; Sun, Xiaolin1; Zhao, Jing1; Yu, Di2; Li, Zhanguo1|
|关键词||rheumatoid arthritis Sjogren&prime s syndrome disease activity|
|WOS标题词||Science & Technology|
|关键词[WOS]||CLINICAL-MANIFESTATIONS ; CARDIOVASCULAR RISK ; DISEASE-ACTIVITY ; CLASSIFICATION ; CRITERIA|
Objective. To compare features of SS in RA with primary SS and RA without SS.
Methods. Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy-four cases of overlap RA and SS (RA/SS) among 509 cases of RA were identified. Cases of SS (n = 187) detected during the same period acted as controls.
Results. Among those with RA/SS, there were 46 cases of RA-onset SS and 12 cases of SS-onset RA. Sixteen patients had simultaneous-onset RA and SS. Compared with RA without SS, RA/SS patients had more severe arthritis; a higher incidence of haematological abnormality, fever and rash; and a higher frequency of RF, ANAs and anti-SSA and anti-SSB antibodies (P < 0.05). Compared with primary SS, RA/SS patients were older, had more severe arthritis, anaemia and lung involvement; a lower incidence of fever, rash, leucopenia, thrombocytopenia and hyperthyroidism; and a higher frequency of RF, anti-keratin antibody, anti-perinuclear factor and anti-cyclic citrullinated antibodies (P < 0.05). Compared with RA and primary SS, RA/SS patients had higher disease activity scores of both RA and SS.
Conclusion. RA/SS patients have distinctive features, with more complications and systemic involvement. In addition, disease activity is higher in RA/SS.
|项目编号||7102155 ; 31070788 ; 81128012|
|资助机构||Beijing Natural Science Foundation ; National Natural Science Foundation of China|
|作者单位||1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China|
2.Monash Univ, Sch Biomed Sci, Dept Immunol Clayton, Clayton, Vic 3800, Australia
|He, Jing,Ding, Yan,Feng, Min,et al. Characteristics of Sjogren′s syndrome in rheumatoid arthritis[J]. RHEUMATOLOGY,2013,52(6):1084-1089.|
|APA||He, Jing.,Ding, Yan.,Feng, Min.,Guo, Jianping.,Sun, Xiaolin.,...&Li, Zhanguo.(2013).Characteristics of Sjogren′s syndrome in rheumatoid arthritis.RHEUMATOLOGY,52(6),1084-1089.|
|MLA||He, Jing,et al."Characteristics of Sjogren′s syndrome in rheumatoid arthritis".RHEUMATOLOGY 52.6(2013):1084-1089.|