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Characteristics of Sjogren′s syndrome in rheumatoid arthritis
He, Jing1; Ding, Yan1; Feng, Min1; Guo, Jianping1; Sun, Xiaolin1; Zhao, Jing1; Yu, Di2; Li, Zhanguo1
关键词rheumatoid arthritis Sjogren&prime s syndrome disease activity
刊名RHEUMATOLOGY
2013-06-01
DOI10.1093/rheumatology/kes374
52期:6页:1084-1089
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]CLINICAL-MANIFESTATIONS ; CARDIOVASCULAR RISK ; DISEASE-ACTIVITY ; CLASSIFICATION ; CRITERIA
英文摘要

Objective. To compare features of SS in RA with primary SS and RA without SS.

Methods. Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy-four cases of overlap RA and SS (RA/SS) among 509 cases of RA were identified. Cases of SS (n = 187) detected during the same period acted as controls.

Results. Among those with RA/SS, there were 46 cases of RA-onset SS and 12 cases of SS-onset RA. Sixteen patients had simultaneous-onset RA and SS. Compared with RA without SS, RA/SS patients had more severe arthritis; a higher incidence of haematological abnormality, fever and rash; and a higher frequency of RF, ANAs and anti-SSA and anti-SSB antibodies (P < 0.05). Compared with primary SS, RA/SS patients were older, had more severe arthritis, anaemia and lung involvement; a lower incidence of fever, rash, leucopenia, thrombocytopenia and hyperthyroidism; and a higher frequency of RF, anti-keratin antibody, anti-perinuclear factor and anti-cyclic citrullinated antibodies (P < 0.05). Compared with RA and primary SS, RA/SS patients had higher disease activity scores of both RA and SS.

Conclusion. RA/SS patients have distinctive features, with more complications and systemic involvement. In addition, disease activity is higher in RA/SS.

语种英语
WOS记录号WOS:000319460000015
项目编号7102155 ; 31070788 ; 81128012
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65202
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
北京大学第三临床医学院_口腔科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Monash Univ, Sch Biomed Sci, Dept Immunol Clayton, Clayton, Vic 3800, Australia
推荐引用方式
GB/T 7714
He, Jing,Ding, Yan,Feng, Min,et al. Characteristics of Sjogren&prime;s syndrome in rheumatoid arthritis[J]. RHEUMATOLOGY,2013,52(6):1084-1089.
APA He, Jing.,Ding, Yan.,Feng, Min.,Guo, Jianping.,Sun, Xiaolin.,...&Li, Zhanguo.(2013).Characteristics of Sjogren′s syndrome in rheumatoid arthritis.RHEUMATOLOGY,52(6),1084-1089.
MLA He, Jing,et al."Characteristics of Sjogren′s syndrome in rheumatoid arthritis".RHEUMATOLOGY 52.6(2013):1084-1089.
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