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学科主题: 临床医学
题名:
Characteristics of Sjogren′s syndrome in rheumatoid arthritis
作者: He, Jing1; Ding, Yan1; Feng, Min1; Guo, Jianping1; Sun, Xiaolin1; Zhao, Jing1; Yu, Di2; Li, Zhanguo1
关键词: rheumatoid arthritis ; Sjogren&prime ; s syndrome ; disease activity
刊名: RHEUMATOLOGY
发表日期: 2013-06-01
DOI: 10.1093/rheumatology/kes374
卷: 52, 期:6, 页:1084-1089
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: CLINICAL-MANIFESTATIONS ; CARDIOVASCULAR RISK ; DISEASE-ACTIVITY ; CLASSIFICATION ; CRITERIA
英文摘要:

Objective. To compare features of SS in RA with primary SS and RA without SS.

Methods. Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy-four cases of overlap RA and SS (RA/SS) among 509 cases of RA were identified. Cases of SS (n = 187) detected during the same period acted as controls.

Results. Among those with RA/SS, there were 46 cases of RA-onset SS and 12 cases of SS-onset RA. Sixteen patients had simultaneous-onset RA and SS. Compared with RA without SS, RA/SS patients had more severe arthritis; a higher incidence of haematological abnormality, fever and rash; and a higher frequency of RF, ANAs and anti-SSA and anti-SSB antibodies (P < 0.05). Compared with primary SS, RA/SS patients were older, had more severe arthritis, anaemia and lung involvement; a lower incidence of fever, rash, leucopenia, thrombocytopenia and hyperthyroidism; and a higher frequency of RF, anti-keratin antibody, anti-perinuclear factor and anti-cyclic citrullinated antibodies (P < 0.05). Compared with RA and primary SS, RA/SS patients had higher disease activity scores of both RA and SS.

Conclusion. RA/SS patients have distinctive features, with more complications and systemic involvement. In addition, disease activity is higher in RA/SS.

语种: 英语
所属项目编号: 7102155 ; 31070788 ; 81128012
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000319460000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65202
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Monash Univ, Sch Biomed Sci, Dept Immunol Clayton, Clayton, Vic 3800, Australia

Recommended Citation:
He, Jing,Ding, Yan,Feng, Min,et al. Characteristics of Sjogren&prime;s syndrome in rheumatoid arthritis[J]. RHEUMATOLOGY,2013,52(6):1084-1089.
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