IR@PKUHSC  > 北京大学第三临床医学院  > 胸外科
学科主题临床医学
Mechanical Pleurodesis Does Not Reduce Recurrence of Spontaneous Pneumothorax: A Randomized Trial
Min, Xianjun; Huang, Yuqing; Yang, Yingshun; Chen, Yingtai; Cui, Jian; Wang, Chong; Huang, Yueqin; Liu, Jun; Wang, Jun
刊名ANNALS OF THORACIC SURGERY
2014-11-01
DOI10.1016/j.athoracsur.2014.06.034
98期:5页:1790-1796
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Respiratory System ; Surgery
研究领域[WOS]Cardiovascular System & Cardiology ; Respiratory System ; Surgery
关键词[WOS]ASSISTED THORACIC-SURGERY ; PLEURAL ABRASION ; THORACOSCOPIC BULLECTOMY ; ADDITIONAL PLEURODESIS ; MANAGEMENT ; LONG
英文摘要

Background. Mechanical pleurodesis is widely used to treat primary spontaneous pneumothorax to decrease postoperative recurrence after thoracoscopic bullectomy, but it is unclear whether it actually reduces primary spontaneous pneumothorax recurrence. We aimed to investigate the effectiveness of mechanical pleurodesis after thoracoscopic treatment of primary spontaneous pneumothorax.

Methods. In our parallel-group, prospective, randomized, controlled trail at 2 hospitals in China, 289 patients were enrolled from January 2010 to January 2013. Patients were randomly assigned (1:1) to receive thoracoscopic wedge resection only (WR group) or thoracoscopic wedge resection and mechanical pleurodesis (WR+MP group). This trial is registered with ClinicalTrial.gov (NCT01463553).

Results. Intraoperative bleeding and postoperative pleural drainage were significantly lower in the thoracoscopic WR only group. Postoperative recurrence rate did not significantly differ between groups (log-rank test p = 0.791; Breslow test p = 0.722). In the thoracoscopic WR only group, no recurrences were found when bullae were isolated or limited; recurrence was 7.5% with the presence of multiple bullae. Younger patients had an increased risk of recurrence (relative risk 3.015; 95% confidence interval 1.092 to 8.324).

Conclusions. Thoracoscopic mechanical pleurodesis did not significantly decrease primary spontaneous pneumothorax recurrence compared with simple wedge resection, but intraoperative bleeding and postoperative pleural drainage rates were higher. Younger age increases the risk of recurrence. (C) 2014 by The Society of Thoracic Surgeons

语种英语
WOS记录号WOS:000344746600065
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65204
Collection北京大学第三临床医学院_胸外科
作者单位1.Peking Univ, Dept Thorac Surg, Beijing Haidian Hosp, Haidian Sect,Hosp 3, Beijing 100871, Peoples R China
2.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100871, Peoples R China
3.Peking Univ, Dept Thorac Surg, Peoples Hosp, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Min, Xianjun,Huang, Yuqing,Yang, Yingshun,et al. Mechanical Pleurodesis Does Not Reduce Recurrence of Spontaneous Pneumothorax: A Randomized Trial[J]. ANNALS OF THORACIC SURGERY,2014,98(5):1790-1796.
APA Min, Xianjun.,Huang, Yuqing.,Yang, Yingshun.,Chen, Yingtai.,Cui, Jian.,...&Wang, Jun.(2014).Mechanical Pleurodesis Does Not Reduce Recurrence of Spontaneous Pneumothorax: A Randomized Trial.ANNALS OF THORACIC SURGERY,98(5),1790-1796.
MLA Min, Xianjun,et al."Mechanical Pleurodesis Does Not Reduce Recurrence of Spontaneous Pneumothorax: A Randomized Trial".ANNALS OF THORACIC SURGERY 98.5(2014):1790-1796.
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