IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis
Murata, Satoru1; Tajima, Hiroyuki1; Ichikawa, Kazuo1; Onozawa, Shiro1; Wang, Jian1,2; Kumita, Shinichiro1; Nomura, Kazuhiro3
关键词interventional procedures embolization embolization materials degradable starch microspheres liver cirrhosis liver cancer
刊名HEPATO-GASTROENTEROLOGY
2008-05-01
55期:84页:1041-1046
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]UNRESECTABLE HEPATOCELLULAR-CARCINOMA ; HEPATIC-ARTERY EMBOLIZATION ; TUMOR-BEARING RABBITS ; LIPIODOL CHEMOEMBOLIZATION ; RANDOMIZED-TRIAL ; LIVER ; MICROCIRCULATION
英文摘要

Background/Aims: To assess efficacy of transcatheter arterial chemoembolization (TACE) combined with degradable starch microspheres (DSM) for patients with liver cirrhosis and hepatocellular carcinoma (HCC).

Methodology: Our studied population was 19 patients with unresectable HCC and liver dysfunction due to repeated TACE, in whom we were unable to selectively advance a microcatheter into the feeding arteries because of tortuous or complex feeding arteries to the HCC. To avoid embolization of an extended non-tumorous area, we conducted Lipiodol-TACE after DSM-embolization (TACE-DSM) of the tumor-free parenchyma. Embolization data and clinical parameters were prospectively assessed.

Results: TACE-DSM was performed 21 times in the 19 patients, and the overall technical success rate was 81%. The TACE-DSM method did not induce severe liver dysfunction. A favorable response involving necrosis of more than 80% or 50% of the tumor was seen in 62% and 90% of cases, respectively. In the follow-up period (8 to 36 months), complete necrosis of the targeted tumors was observed in 26% of cases. The 2-year survival rates calculated as starting from the date of TACE-DSM therapy was 32.6%.

Conclusions: From these results we conclude that TACE-DSM therapy is useful for protecting liver function in patients with cirrhosis and unresectable HCC.

语种英语
WOS记录号WOS:000257357600052
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65207
Collection北京大学第一临床医学院_放射治疗科
作者单位1.Beijing Univ, Dept Radiol, Hosp 1, Beijing, Peoples R China
2.Natl Canc Ctr, Tokyo, Japan
3.Nippon Med Sch, Dept Radiol, Ctr Adv Med Technol, Tokyo 113, Japan
Recommended Citation
GB/T 7714
Murata, Satoru,Tajima, Hiroyuki,Ichikawa, Kazuo,et al. Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis[J]. HEPATO-GASTROENTEROLOGY,2008,55(84):1041-1046.
APA Murata, Satoru.,Tajima, Hiroyuki.,Ichikawa, Kazuo.,Onozawa, Shiro.,Wang, Jian.,...&Nomura, Kazuhiro.(2008).Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis.HEPATO-GASTROENTEROLOGY,55(84),1041-1046.
MLA Murata, Satoru,et al."Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis".HEPATO-GASTROENTEROLOGY 55.84(2008):1041-1046.
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