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学科主题: 临床医学
题名:
Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis
作者: Murata, Satoru1; Tajima, Hiroyuki1; Ichikawa, Kazuo1; Onozawa, Shiro1; Wang, Jian1,2; Kumita, Shinichiro1; Nomura, Kazuhiro3
关键词: interventional procedures ; embolization ; embolization materials ; degradable starch microspheres ; liver cirrhosis ; liver cancer
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2008-05-01
卷: 55, 期:84, 页:1041-1046
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: UNRESECTABLE HEPATOCELLULAR-CARCINOMA ; HEPATIC-ARTERY EMBOLIZATION ; TUMOR-BEARING RABBITS ; LIPIODOL CHEMOEMBOLIZATION ; RANDOMIZED-TRIAL ; LIVER ; MICROCIRCULATION
英文摘要:

Background/Aims: To assess efficacy of transcatheter arterial chemoembolization (TACE) combined with degradable starch microspheres (DSM) for patients with liver cirrhosis and hepatocellular carcinoma (HCC).

Methodology: Our studied population was 19 patients with unresectable HCC and liver dysfunction due to repeated TACE, in whom we were unable to selectively advance a microcatheter into the feeding arteries because of tortuous or complex feeding arteries to the HCC. To avoid embolization of an extended non-tumorous area, we conducted Lipiodol-TACE after DSM-embolization (TACE-DSM) of the tumor-free parenchyma. Embolization data and clinical parameters were prospectively assessed.

Results: TACE-DSM was performed 21 times in the 19 patients, and the overall technical success rate was 81%. The TACE-DSM method did not induce severe liver dysfunction. A favorable response involving necrosis of more than 80% or 50% of the tumor was seen in 62% and 90% of cases, respectively. In the follow-up period (8 to 36 months), complete necrosis of the targeted tumors was observed in 26% of cases. The 2-year survival rates calculated as starting from the date of TACE-DSM therapy was 32.6%.

Conclusions: From these results we conclude that TACE-DSM therapy is useful for protecting liver function in patients with cirrhosis and unresectable HCC.

语种: 英语
WOS记录号: WOS:000257357600052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65207
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Beijing Univ, Dept Radiol, Hosp 1, Beijing, Peoples R China
2.Natl Canc Ctr, Tokyo, Japan
3.Nippon Med Sch, Dept Radiol, Ctr Adv Med Technol, Tokyo 113, Japan

Recommended Citation:
Murata, Satoru,Tajima, Hiroyuki,Ichikawa, Kazuo,et al. Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis[J]. HEPATO-GASTROENTEROLOGY,2008,55(84):1041-1046.
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