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学科主题: 临床医学
题名:
XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer
作者: Li Ming; Song Tao; Yin Zhen-fei; Na Yan-qun
关键词: XIAP ; urinary bladder neoplasms ; recurrence
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2007-03-20
卷: 120, 期:6, 页:469-473
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: X-LINKED INHIBITOR ; TRANSITIONAL-CELL CARCINOMA ; APOPTOSIS ; EXPRESSION ; PROGRESSION ; SURVIVIN ; PROTEINS ; PATHWAY
英文摘要:

Background Dysregulation of apoptosis has been implicated not only in carcinogenesis and tumor progression but also in tumor recurrence. We investigated whether the expression of X-linked inhibitor of apoptosis (XIAP) might predict early recurrence in patients with non-muscular invasive bladder cancer.

Methods The cohort comprised 176 consecutive patients with primary superficial bladder cancer treated with transurethral resection. Immunohistochemical staining using the standard avidin-biotin-peroxidase technique and RT-PCR were used to detect XIAP protein and mRNA expressions in cancer tissues. The relationship between XIAP expression and clinicopathological characteristics, cancer recurrence were analyzed.

Results XIAP expression was observed in 108 cases (61.4%) and no expression in 68. There was no correlation between XIAP expression rate and the tumor pathological grade, but was an apparent trend toward the increased XIAP levels from well (G1) to poor (G3) differentiated cancer. Eighty-two (46.6%) patients experienced tumor recurrence at a mean of 28.6 months of the follow-up; 66 of them expressed XIAP (61.1%) and 16 were XIAP negative (23.5%). Twelve patients presented with invasive disease at the time of relapse and all of them expressed XIAR Patients without XIAP expression or with low tumor grades had significantly higher recurrence-free survival than those with XIAP expression (log rank test P=0.0015) or high tumor grades (log rank test P < 0.001). Multivariate analysis revealed that XIAP expression, tumor grade, and tumor number were independent predictors for the recurrence of non-muscular invasive bladder cancer (P=0.004, 0.016, and 0.043, respectively).

Conclusions XIAP may be considered as a new independent prognostic marker for early recurrence of non-muscular invasive bladder cancer.

语种: 英语
WOS记录号: WOS:000245453400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65209
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China

Recommended Citation:
Li Ming,Song Tao,Yin Zhen-fei,et al. XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer[J]. CHINESE MEDICAL JOURNAL,2007,120(6):469-473.
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