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XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer
Li Ming; Song Tao; Yin Zhen-fei; Na Yan-qun
关键词XIAP urinary bladder neoplasms recurrence
刊名CHINESE MEDICAL JOURNAL
2007-03-20
120期:6页:469-473
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]X-LINKED INHIBITOR ; TRANSITIONAL-CELL CARCINOMA ; APOPTOSIS ; EXPRESSION ; PROGRESSION ; SURVIVIN ; PROTEINS ; PATHWAY
英文摘要

Background Dysregulation of apoptosis has been implicated not only in carcinogenesis and tumor progression but also in tumor recurrence. We investigated whether the expression of X-linked inhibitor of apoptosis (XIAP) might predict early recurrence in patients with non-muscular invasive bladder cancer.

Methods The cohort comprised 176 consecutive patients with primary superficial bladder cancer treated with transurethral resection. Immunohistochemical staining using the standard avidin-biotin-peroxidase technique and RT-PCR were used to detect XIAP protein and mRNA expressions in cancer tissues. The relationship between XIAP expression and clinicopathological characteristics, cancer recurrence were analyzed.

Results XIAP expression was observed in 108 cases (61.4%) and no expression in 68. There was no correlation between XIAP expression rate and the tumor pathological grade, but was an apparent trend toward the increased XIAP levels from well (G1) to poor (G3) differentiated cancer. Eighty-two (46.6%) patients experienced tumor recurrence at a mean of 28.6 months of the follow-up; 66 of them expressed XIAP (61.1%) and 16 were XIAP negative (23.5%). Twelve patients presented with invasive disease at the time of relapse and all of them expressed XIAR Patients without XIAP expression or with low tumor grades had significantly higher recurrence-free survival than those with XIAP expression (log rank test P=0.0015) or high tumor grades (log rank test P < 0.001). Multivariate analysis revealed that XIAP expression, tumor grade, and tumor number were independent predictors for the recurrence of non-muscular invasive bladder cancer (P=0.004, 0.016, and 0.043, respectively).

Conclusions XIAP may be considered as a new independent prognostic marker for early recurrence of non-muscular invasive bladder cancer.

语种英语
WOS记录号WOS:000245453400006
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65209
专题北京大学第一临床医学院_泌尿外科
作者单位Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
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Li Ming,Song Tao,Yin Zhen-fei,et al. XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer[J]. CHINESE MEDICAL JOURNAL,2007,120(6):469-473.
APA Li Ming,Song Tao,Yin Zhen-fei,&Na Yan-qun.(2007).XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer.CHINESE MEDICAL JOURNAL,120(6),469-473.
MLA Li Ming,et al."XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer".CHINESE MEDICAL JOURNAL 120.6(2007):469-473.
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