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学科主题: 基础医学
题名:
The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm
作者: Wang, Jun1,2; Chan, Chung-Kit1; Taylor, Jeremy S. H.3; Chan, Sun-On1
关键词: axon guidance ; retina ; retinofugal pathway ; midline ; visual system ; axon growth
刊名: JOURNAL OF NEUROSCIENCE RESEARCH
发表日期: 2008-09-01
DOI: 10.1002/jnr.21717
卷: 86, 期:12, 页:2581-2590
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CHONDROITIN SULFATE ; RETINOFUGAL PATHWAY ; NEURITE OUTGROWTH ; RETINAL AXONS ; CELL-CYCLE ; EMBRYOS ; REGENERATION ; RECEPTOR ; DIVERGENCE ; IDENTIFICATION
英文摘要:

We have investigated the role of Nogo, a protein that inhibits regenerating axons in the adult central nervous system, on axon guidance in the developing optic chiasm of mouse embryos. Nogo protein is expressed by radial glia in the midline within the optic chiasm where uncrossed axons turn, and the Nogo receptor (NgR) is expressed on retinal neurites and growth cones. In vitro neurite outgrowth from both dorsonasal and ventrotemporal retina was inhibited by Nogo protein, and this inhibition was abolished by blocking NgR activity. In slice cultures of the optic pathway, blocking NgR with a peptide antagonist produced significant reduction in the uncrossed projection but had no effect on the crossing axons. This result was confirmed by treating cultures with an anti-Nogo functional blocking antibody. In vitro coculture assays of retina and optic chiasm showed that NgR was selectively reduced on neurites and growth cones from dorsonasal retina when they contacted chiasm cells, but not on those from ventrotemporal retina. These findings provide evidence that Nogo signaling is involved in directing the growth of axons in the mouse optic chiasm and that this process relies on a differential regulation of NgR on axons from the dorsonasal and ventrotemporal retina. (C) 2008 Wiley-Liss, Inc.

语种: 英语
所属项目编号: CUHK 4417/03M ; CUHK 4420/05M
项目资助者: Research Grant Council of the Hong Kong Special Administrative Region
WOS记录号: WOS:000259051900001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65210
Appears in Collections:基础医学院_解剖学与组织胚胎学系_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100871, Peoples R China
3.Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

Recommended Citation:
Wang, Jun,Chan, Chung-Kit,Taylor, Jeremy S. H.,et al. The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(12):2581-2590.
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