学科主题基础医学
The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm
Wang, Jun1,2; Chan, Chung-Kit1; Taylor, Jeremy S. H.3; Chan, Sun-On1
关键词axon guidance retina retinofugal pathway midline visual system axon growth
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2008-09-01
DOI10.1002/jnr.21717
86期:12页:2581-2590
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CHONDROITIN SULFATE ; RETINOFUGAL PATHWAY ; NEURITE OUTGROWTH ; RETINAL AXONS ; CELL-CYCLE ; EMBRYOS ; REGENERATION ; RECEPTOR ; DIVERGENCE ; IDENTIFICATION
英文摘要

We have investigated the role of Nogo, a protein that inhibits regenerating axons in the adult central nervous system, on axon guidance in the developing optic chiasm of mouse embryos. Nogo protein is expressed by radial glia in the midline within the optic chiasm where uncrossed axons turn, and the Nogo receptor (NgR) is expressed on retinal neurites and growth cones. In vitro neurite outgrowth from both dorsonasal and ventrotemporal retina was inhibited by Nogo protein, and this inhibition was abolished by blocking NgR activity. In slice cultures of the optic pathway, blocking NgR with a peptide antagonist produced significant reduction in the uncrossed projection but had no effect on the crossing axons. This result was confirmed by treating cultures with an anti-Nogo functional blocking antibody. In vitro coculture assays of retina and optic chiasm showed that NgR was selectively reduced on neurites and growth cones from dorsonasal retina when they contacted chiasm cells, but not on those from ventrotemporal retina. These findings provide evidence that Nogo signaling is involved in directing the growth of axons in the mouse optic chiasm and that this process relies on a differential regulation of NgR on axons from the dorsonasal and ventrotemporal retina. (C) 2008 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000259051900001
项目编号CUHK 4417/03M ; CUHK 4420/05M
资助机构Research Grant Council of the Hong Kong Special Administrative Region
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65210
专题北京大学基础医学院_解剖学与组织胚胎学系
北京大学基础医学院
作者单位1.Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100871, Peoples R China
3.Univ Oxford, Dept Physiol Anat & Genet, Oxford, England
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GB/T 7714
Wang, Jun,Chan, Chung-Kit,Taylor, Jeremy S. H.,et al. The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(12):2581-2590.
APA Wang, Jun,Chan, Chung-Kit,Taylor, Jeremy S. H.,&Chan, Sun-On.(2008).The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm.JOURNAL OF NEUROSCIENCE RESEARCH,86(12),2581-2590.
MLA Wang, Jun,et al."The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm".JOURNAL OF NEUROSCIENCE RESEARCH 86.12(2008):2581-2590.
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