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Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP)
Sun, Q; Li, RT; Guo, W; Cui, JR; Cheng, TM; Ge, ZM
关键词prodrug cyclophosphamide cyclophosphamide spiropiperaziniums anti-cancer synthesis
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2006-07-15
DOI10.1016/j.bmcl.2006.04.049
16期:14页:3727-3730
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]UNIQUE SPIROCYCLOPIPERAZINIUM SALT ; ANTI-TUMOR ACTIVITY ; ALDOPHOSPHAMIDE ANALOGS ; ANTITUMOR-ACTIVITY ; ALKYLATING-AGENTS ; DT-DIAPHORASE ; DERIVATIVES ; METABOLISM ; ANALGESICS ; ACTIVATION
英文摘要

A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S-180 and H-22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure-activity relationships were revealed. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000238698400020
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65212
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Sun, Q,Li, RT,Guo, W,et al. Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP)[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(14):3727-3730.
APA Sun, Q,Li, RT,Guo, W,Cui, JR,Cheng, TM,&Ge, ZM.(2006).Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP).BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(14),3727-3730.
MLA Sun, Q,et al."Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP)".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.14(2006):3727-3730.
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