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学科主题: 基础医学
题名:
PD-1 expression on peripheral CD8+TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients
作者: Shen, Tao1; Zheng, Jiajia1; Xu, Chunhui1; Liu, Jia1; Zhang, Weidong2; Lu, Fengmin1; Zhuang, Hui1
刊名: VIROLOGY JOURNAL
发表日期: 2010-11-12
DOI: 10.1186/1743-422X-7-310
卷: 7, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: CD8(+) T-CELLS ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; COMMERCIAL PLASMA DONORS ; HIV-INFECTION ; MEMORY CELLS ; CD127 EXPRESSION ; EFFECTOR ; LYMPHOCYTES ; INTERLEUKIN-7 ; RESPONSES
英文摘要:

Background: Tight correlation between host circulating CD8+ T cell-mediated immune response and control of viral replication is classical characteristic of long-term HCV infection. CD8+ T cell maturation/activation markers are expected to be associated with viral replication and disease progression in chronic HCV infection. The aim of the present study was to explore novel markers on CD8+ T cells with ability to evaluate HCV viral replication and disease progression.

Methods: PBMCs were isolated from 37 chronic HCV-infected patients and 17 healthy controls. Distributed pattern of CD8+ T cells subsets and expression of PD-1, CD38, HLA-DR and CD127 were analyzed by flow cytometry. The correlation between expression of surface markers and HCV viral load or ALT was studied.

Results: Declined naive and increased TEMRA CD8+ T subsets were found in HCV-infected individuals compared with healthy controls. Percentage and MFI of PD-1, CD38 and HLA-DR on all CD8+ T cell subsets were higher in HCV-infected patients than healthy controls. In contrast, CD127 expression on CD8+ TCM showed an opposite trend as PD-1, CD38 and HLA-DR did. In chronic HCV infection, MFI of PD-1 on CD8+ TEM (p < 0.0001) and TEMRA (p = 0.0015) was positively correlated with HCV viral load while HLA-DR expression on non-naive CD8+ T cell subsets (p < 0.05) was negatively correlated with HCV viral load.

Conclusion: PD-1 level on peripheral CD8+ TEM/TEMRA was highly correlated with HCV viral load in chronic HCV-infected patients, which made PD-1 a novel indicator to evaluate HCV replication and disease progression in chronic hepatitis C patients.

语种: 英语
所属项目编号: 2008ZX10002-013
项目资助者: China National ST Major Project
WOS记录号: WOS:000284525400001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65217
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Zhengzhou Univ, Dept Epidemiol, Coll Publ Hlth, Zhengzhou 450052, Henan, Peoples R China

Recommended Citation:
Shen, Tao,Zheng, Jiajia,Xu, Chunhui,et al. PD-1 expression on peripheral CD8+TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients[J]. VIROLOGY JOURNAL,2010,7(1).
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