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学科主题基础医学
PD-1 expression on peripheral CD8+TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients
Shen, Tao1; Zheng, Jiajia1; Xu, Chunhui1; Liu, Jia1; Zhang, Weidong2; Lu, Fengmin1; Zhuang, Hui1
刊名VIROLOGY JOURNAL
2010-11-12
DOI10.1186/1743-422X-7-310
7期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]CD8(+) T-CELLS ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; COMMERCIAL PLASMA DONORS ; HIV-INFECTION ; MEMORY CELLS ; CD127 EXPRESSION ; EFFECTOR ; LYMPHOCYTES ; INTERLEUKIN-7 ; RESPONSES
英文摘要

Background: Tight correlation between host circulating CD8+ T cell-mediated immune response and control of viral replication is classical characteristic of long-term HCV infection. CD8+ T cell maturation/activation markers are expected to be associated with viral replication and disease progression in chronic HCV infection. The aim of the present study was to explore novel markers on CD8+ T cells with ability to evaluate HCV viral replication and disease progression.

Methods: PBMCs were isolated from 37 chronic HCV-infected patients and 17 healthy controls. Distributed pattern of CD8+ T cells subsets and expression of PD-1, CD38, HLA-DR and CD127 were analyzed by flow cytometry. The correlation between expression of surface markers and HCV viral load or ALT was studied.

Results: Declined naive and increased TEMRA CD8+ T subsets were found in HCV-infected individuals compared with healthy controls. Percentage and MFI of PD-1, CD38 and HLA-DR on all CD8+ T cell subsets were higher in HCV-infected patients than healthy controls. In contrast, CD127 expression on CD8+ TCM showed an opposite trend as PD-1, CD38 and HLA-DR did. In chronic HCV infection, MFI of PD-1 on CD8+ TEM (p < 0.0001) and TEMRA (p = 0.0015) was positively correlated with HCV viral load while HLA-DR expression on non-naive CD8+ T cell subsets (p < 0.05) was negatively correlated with HCV viral load.

Conclusion: PD-1 level on peripheral CD8+ TEM/TEMRA was highly correlated with HCV viral load in chronic HCV-infected patients, which made PD-1 a novel indicator to evaluate HCV replication and disease progression in chronic hepatitis C patients.

语种英语
WOS记录号WOS:000284525400001
项目编号2008ZX10002-013
资助机构China National ST Major Project
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65217
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学口腔医学院_第一门诊部
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Zhengzhou Univ, Dept Epidemiol, Coll Publ Hlth, Zhengzhou 450052, Henan, Peoples R China
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GB/T 7714
Shen, Tao,Zheng, Jiajia,Xu, Chunhui,et al. PD-1 expression on peripheral CD8+TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients[J]. VIROLOGY JOURNAL,2010,7(1).
APA Shen, Tao.,Zheng, Jiajia.,Xu, Chunhui.,Liu, Jia.,Zhang, Weidong.,...&Zhuang, Hui.(2010).PD-1 expression on peripheral CD8+TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients.VIROLOGY JOURNAL,7(1).
MLA Shen, Tao,et al."PD-1 expression on peripheral CD8+TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients".VIROLOGY JOURNAL 7.1(2010).
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