IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients
Zheng, Jinxin3; Zeng, Zheng3; Zhang, Duyi3; Yu, Yanyan3; Wang, Fang3; Pan, Calvin Q.1,2
关键词clinical outcomes hepatitis B virus mutations naive reverse transcriptase
刊名LIVER INTERNATIONAL
2012-11-01
DOI10.1111/j.1478-3231.2012.02859.x
32期:10页:1535-1542
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ANTIVIRAL RESISTANCE MUTATIONS ; NUCLEOSIDE-NAIVE PATIENTS ; LAMIVUDINE TREATMENT ; ADEFOVIR DIPIVOXIL ; VIRUS-INFECTION ; HBV ; POLYMERASE ; NOMENCLATURE ; ENTECAVIR ; SEQUENCES
英文摘要

Aims Hepatitis B virus (HBV) reverse transcriptase (RT) mutants, which have not been well characterized according to different disease stages. This study aimed to characterize the profiles of naturally occurring mutations in the HBV RT region and their associated clinical outcomes. Methods HBV RT region mutations and genotypes were determined by PCR-direct sequencing and compared with p-distance model. Results Among 467 consecutive eligible patients (262 chronic hepatitis B patients, 105 cirrhotic patients and 100 hepatocellular carcinoma patients), the nucleos(t)ide analogues-related mutations (rtI169T, rtV173L, rtL180M, rtA181T, rtS202C, rtM204I/V, rtN236T) were found. The p-distance value reached a peak in the age of 2030 years in the CHB patients and in the age of 4045 years in the cirrhotic patients and hepatocellular carcinoma patients. The naturally occurring mutation, rtS106C mutation was higher in chronic hepatitis B patients (14/100, 14.0%) and cirrhotic patients (14/100, 14.0%) than that in hepatocellular carcinoma patients (4/100, 4.0%, P = 0.013). And the rtD134E/G/N/S mutations were also higher in chronic hepatitis B patients (22/100, 22.0%) and cirrhotic patients (21/100, 21.0%) than that in hepatocellular carcinoma patients (10/100, 10.0%, P = 0.021 and P = 0.032 respectively). The mutation frequencies in AB interdomain were higher in cirrhotic patients (101/1900, 5.3%) than that in hepatocellular carcinoma patients (68/1900, 3.6%) (P = 0.009). Conclusions The nucleos(t)ide analogues-related mutations do exist in treatment naive patients with different disease stages. rtS106C, rtD134E/G/N/S and AB interdomain mutations may be associated with necro-inflammation, immune response and cirrhosis development at ages older than 40.

语种英语
WOS记录号WOS:000309448900009
项目编号30671855 ; N01-CO-12400 ; 008ZX10002004
资助机构National Nature Science Foundation of China ; National Cancer Institute, National Institute of Health ; Major Science and Technology Special Project of China Eleventh Five-year Plan
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65221
专题北京大学第一临床医学院_感染疾病科
作者单位1.Mt Sinai Hosp, Mt Sinai Sch Med, Mt Sinai Med Ctr, Div Liver Dis,Dept Med, New York, NY 10029 USA
2.New Discovery, Flushing, NY USA
3.Peking Univ First Hosp, Dept Infect Dis, Virol Lab, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Jinxin,Zeng, Zheng,Zhang, Duyi,et al. Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients[J]. LIVER INTERNATIONAL,2012,32(10):1535-1542.
APA Zheng, Jinxin,Zeng, Zheng,Zhang, Duyi,Yu, Yanyan,Wang, Fang,&Pan, Calvin Q..(2012).Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.LIVER INTERNATIONAL,32(10),1535-1542.
MLA Zheng, Jinxin,et al."Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients".LIVER INTERNATIONAL 32.10(2012):1535-1542.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, Jinxin]的文章
[Zeng, Zheng]的文章
[Zhang, Duyi]的文章
百度学术
百度学术中相似的文章
[Zheng, Jinxin]的文章
[Zeng, Zheng]的文章
[Zhang, Duyi]的文章
必应学术
必应学术中相似的文章
[Zheng, Jinxin]的文章
[Zeng, Zheng]的文章
[Zhang, Duyi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。