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学科主题: 临床医学
题名:
Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients
作者: Zheng, Jinxin3; Zeng, Zheng3; Zhang, Duyi3; Yu, Yanyan3; Wang, Fang3; Pan, Calvin Q.1,2
关键词: clinical outcomes ; hepatitis B virus ; mutations ; naive ; reverse transcriptase
刊名: LIVER INTERNATIONAL
发表日期: 2012-11-01
DOI: 10.1111/j.1478-3231.2012.02859.x
卷: 32, 期:10, 页:1535-1542
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ANTIVIRAL RESISTANCE MUTATIONS ; NUCLEOSIDE-NAIVE PATIENTS ; LAMIVUDINE TREATMENT ; ADEFOVIR DIPIVOXIL ; VIRUS-INFECTION ; HBV ; POLYMERASE ; NOMENCLATURE ; ENTECAVIR ; SEQUENCES
英文摘要:

Aims Hepatitis B virus (HBV) reverse transcriptase (RT) mutants, which have not been well characterized according to different disease stages. This study aimed to characterize the profiles of naturally occurring mutations in the HBV RT region and their associated clinical outcomes. Methods HBV RT region mutations and genotypes were determined by PCR-direct sequencing and compared with p-distance model. Results Among 467 consecutive eligible patients (262 chronic hepatitis B patients, 105 cirrhotic patients and 100 hepatocellular carcinoma patients), the nucleos(t)ide analogues-related mutations (rtI169T, rtV173L, rtL180M, rtA181T, rtS202C, rtM204I/V, rtN236T) were found. The p-distance value reached a peak in the age of 2030 years in the CHB patients and in the age of 4045 years in the cirrhotic patients and hepatocellular carcinoma patients. The naturally occurring mutation, rtS106C mutation was higher in chronic hepatitis B patients (14/100, 14.0%) and cirrhotic patients (14/100, 14.0%) than that in hepatocellular carcinoma patients (4/100, 4.0%, P = 0.013). And the rtD134E/G/N/S mutations were also higher in chronic hepatitis B patients (22/100, 22.0%) and cirrhotic patients (21/100, 21.0%) than that in hepatocellular carcinoma patients (10/100, 10.0%, P = 0.021 and P = 0.032 respectively). The mutation frequencies in AB interdomain were higher in cirrhotic patients (101/1900, 5.3%) than that in hepatocellular carcinoma patients (68/1900, 3.6%) (P = 0.009). Conclusions The nucleos(t)ide analogues-related mutations do exist in treatment naive patients with different disease stages. rtS106C, rtD134E/G/N/S and AB interdomain mutations may be associated with necro-inflammation, immune response and cirrhosis development at ages older than 40.

语种: 英语
所属项目编号: 30671855 ; N01-CO-12400 ; 008ZX10002004
项目资助者: National Nature Science Foundation of China ; National Cancer Institute, National Institute of Health ; Major Science and Technology Special Project of China Eleventh Five-year Plan
WOS记录号: WOS:000309448900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65221
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Mt Sinai Hosp, Mt Sinai Sch Med, Mt Sinai Med Ctr, Div Liver Dis,Dept Med, New York, NY 10029 USA
2.New Discovery, Flushing, NY USA
3.Peking Univ First Hosp, Dept Infect Dis, Virol Lab, Beijing, Peoples R China

Recommended Citation:
Zheng, Jinxin,Zeng, Zheng,Zhang, Duyi,et al. Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients[J]. LIVER INTERNATIONAL,2012,32(10):1535-1542.
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