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Increased Variability of Genomic Transcription in Schizophrenia
Zhang, Fuquan1; Shugart, Yin Yao2; Yue, Weihua3,4,5; Cheng, Zaohuo1; Wang, Guoqiang1; Zhou, Zhenhe1; Jin, Chunhui1; Yuan, Jianmin1; Liu, Sha6; Xu, Yong6
刊名SCIENTIFIC REPORTS
2015-12-10
DOI10.1038/srep17995
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University ; Construction Plan for Shanxi Science &amp ; Technology Infrastructure Platforms ; Intramural Research Program of National Institute of Mental Health, National Institutes of Health ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University ; Construction Plan for Shanxi Science &amp ; Technology Infrastructure Platforms ; Intramural Research Program of National Institute of Mental Health, National Institutes of Health
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GENE-EXPRESSION
英文摘要

Schizophrenia (SZ) is a severe chronic mental disorder with a high heritability. Current microarray analyses typically focus on identifying differentially expressed genes or enriched pathways relevant to phenotypes. Whether there is a variability change of the genomic transcription in diseases has rarely been explored. In this study, we compared coefficient of variation (CV, the ratio of the standard deviation to the mean) of genome transcription of early-onset SZ (EOS) patients with controls in a blood mRNA microarray dataset and a blood microRNA (miRNA) microarray dataset. Furthermore, we compared CV of the expression levels of 17 genes in blood of the 30 patients before and after the 12-week treatment using real-time quantitative PCR (RT-qPCR) analysis. Our results indicated a significant increase of CV of genome transcription in patients compared with controls in both the mRNA and the miRNA datasets. The 30 after-treatment patients showed a significant decrease of CV of gene expression compared with the before-treatment patients. Our study may implicate the blood gene expression variability in SZ, providing further evidence supporting the abnormality of peripheral blood transcriptome in SZ. Given that peripheral blood can be easily collected from patients and followed longitudinally, our results may indicate a new way to facilitate the identification of the signatures of clinical subtypes, their prognosis and treatment response.

语种英语
所属项目编号81471364 ; 81271482 ; 7132182 ; NCET-12-1036 ; 2015091002-0102 ; MH002929-04
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University ; Construction Plan for Shanxi Science &amp ; Technology Infrastructure Platforms ; Intramural Research Program of National Institute of Mental Health, National Institutes of Health ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University ; Construction Plan for Shanxi Science &amp ; Technology Infrastructure Platforms ; Intramural Research Program of National Institute of Mental Health, National Institutes of Health
WOS记录号WOS:000366133600002
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65224
专题北京大学精神卫生研究所
作者单位1.Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi, Jiangsu, Peoples R China
2.NIMH, Unit Stat Genom, Div Intramural Res Program, NIH, Bethesda, MD 20892 USA
3.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
5.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
6.Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Fuquan,Shugart, Yin Yao,Yue, Weihua,et al. Increased Variability of Genomic Transcription in Schizophrenia[J]. SCIENTIFIC REPORTS,2015,5.
APA Zhang, Fuquan.,Shugart, Yin Yao.,Yue, Weihua.,Cheng, Zaohuo.,Wang, Guoqiang.,...&Xu, Yong.(2015).Increased Variability of Genomic Transcription in Schizophrenia.SCIENTIFIC REPORTS,5.
MLA Zhang, Fuquan,et al."Increased Variability of Genomic Transcription in Schizophrenia".SCIENTIFIC REPORTS 5(2015).
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