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学科主题: 药学
题名:
Stability and structure studies on alisol A 24-acetate
作者: Makabel, Bolat1,2,3; Zhao, Yuying1,2; Wang, Bin1,2; Bal, Yanjing1,2; Zhang, Qingying1,2; Wu, Li4; Lv, Yang4
关键词: alisol A 24-acetate ; alisol A 23-acetate ; stability ; Rhizoma Alismatis ; Alisma orientalis
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2008
卷: 56, 期:1, 页:41-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ALISMATIS RHIZOMA ; CONSTITUENTS
英文摘要:

Alisol A 24-acetate is one of the main active triterpenoid compounds isolated from Rhizoma Alismatis, which is a famous Traditional Chinese Medicine, and has been determined for the quality control of this crude drug. In this study, alisol A 24-acetate was found to be unstable in solvents and its stability in different solvents was investigated in detail. The results showed that alisol A 24-acetate and 23-acetate inter-transformed in solvents and the transformation rate was more rapid in protic solvents than in aprotic solvents. Moreover, both alisol A 24-acetate and 23-acetate were deacetylated to yield alisol A when kept in methanol for a long time. This is the first report on the structural transformation between alisol A 24-acetate, alisol A 23-acetate and alisol A. In addition, the single crystal X-ray structure of alisol A 24-acetate and the NMR data of alisol A 23-acetate were also reported for the first time.

语种: 英语
WOS记录号: WOS:000252918900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65228
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Xinjiang Inst Chinese Mat Med & Ethnodrug, Urumqi 830002, Peoples R China
4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
Makabel, Bolat,Zhao, Yuying,Wang, Bin,et al. Stability and structure studies on alisol A 24-acetate[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2008,56(1):41-45.
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