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Stability and structure studies on alisol A 24-acetate
Makabel, Bolat1,2,3; Zhao, Yuying1,2; Wang, Bin1,2; Bal, Yanjing1,2; Zhang, Qingying1,2; Wu, Li4; Lv, Yang4
关键词alisol A 24-acetate alisol A 23-acetate stability Rhizoma Alismatis Alisma orientalis
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
2008
56期:1页:41-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ALISMATIS RHIZOMA ; CONSTITUENTS
英文摘要

Alisol A 24-acetate is one of the main active triterpenoid compounds isolated from Rhizoma Alismatis, which is a famous Traditional Chinese Medicine, and has been determined for the quality control of this crude drug. In this study, alisol A 24-acetate was found to be unstable in solvents and its stability in different solvents was investigated in detail. The results showed that alisol A 24-acetate and 23-acetate inter-transformed in solvents and the transformation rate was more rapid in protic solvents than in aprotic solvents. Moreover, both alisol A 24-acetate and 23-acetate were deacetylated to yield alisol A when kept in methanol for a long time. This is the first report on the structural transformation between alisol A 24-acetate, alisol A 23-acetate and alisol A. In addition, the single crystal X-ray structure of alisol A 24-acetate and the NMR data of alisol A 23-acetate were also reported for the first time.

语种英语
WOS记录号WOS:000252918900008
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65228
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Xinjiang Inst Chinese Mat Med & Ethnodrug, Urumqi 830002, Peoples R China
4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Makabel, Bolat,Zhao, Yuying,Wang, Bin,et al. Stability and structure studies on alisol A 24-acetate[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2008,56(1):41-45.
APA Makabel, Bolat.,Zhao, Yuying.,Wang, Bin.,Bal, Yanjing.,Zhang, Qingying.,...&Lv, Yang.(2008).Stability and structure studies on alisol A 24-acetate.CHEMICAL & PHARMACEUTICAL BULLETIN,56(1),41-45.
MLA Makabel, Bolat,et al."Stability and structure studies on alisol A 24-acetate".CHEMICAL & PHARMACEUTICAL BULLETIN 56.1(2008):41-45.
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