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学科主题: 临床医学
题名:
Resiniferatoxin for treatment of lifelong premature ejaculation: A preliminary study
作者: Shi, Bentao1; Li, Xuesong2; Chen, Jing1; Su, Boxing2; Li, Xianxin1; Yang, Shangqi1; Guan, Zhichen1; Wang, Run3,4
关键词: Chinese Index of Sexual Function for Premature Ejaculation ; intravaginal ejaculation latency time ; premature ejaculation ; redundant prepuce ; resiniferatoxin
刊名: INTERNATIONAL JOURNAL OF UROLOGY
发表日期: 2014-09-01
DOI: 10.1111/iju.12471
卷: 21, 期:9, 页:923-926
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: DEFINITION ; EFFICACY ; CREAM
英文摘要:

Objectives: To evaluate the efficacy of resiniferatoxin in the treatment of patients with lifelong premature ejaculation.

Methods: A total of 41 outpatients (mean age 26.14 +/- 4 years) with premature ejaculation completed the present study. They were randomly separated into the resiniferatoxin group and the placebo group. The resiniferatoxin group included 11 patients with redundant prepuce and 10 patients without redundant prepuce, whereas the placebo group contained 10 patients with redundant prepuce and 10 patients without. For the treatment, the glans were respectively soaked in 30 mL of resiniferatoxin with a concentration of 100 nmol/L or 10% alcohol solution for 30 min before sexual intercourse. Clinical efficacy was assessed by using the Chinese Index of Sexual Function for Premature Ejaculation-5 and the intravaginal ejaculation latency time before or 4 weeks after the treatment. The side-effects were also evaluated.

Results: In the resiniferatoxin group, the effective rate of patients with redundant prepuce was 63.6%, and both the intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 significantly increased (P < 0.05). However, the effective rate of patients without redundant prepuce was 20%, and there were no significant changes of their intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 before and after the resiniferatoxin treatment (P > 0.05). The total effective rate of patients treated with resiniferatoxin was 42.9%. In the placebo group, the effective rate of patients with or without redundant prepuce was 20% and 10%, respectively. The total effective rate of patients treated with placebo was 15%, and there were no significant changes of their intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 before and after the placebo treatment (P > 0.05). The side-effects included a slight burning sensation for the glans penis and dysuria.

Conclusions: These preliminary results show that resiniferatoxin might be suitable for treating patients with lifelong premature ejaculation and particularly those with redundant prepuce.

语种: 英语
项目资助者: Shenzhen Science and Technology Innovation Committee
WOS记录号: WOS:000341504400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65231
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518038, Guangdong, Peoples R China
2.Univ Texas Med Sch Houston, Dept Urol, Houston, TX USA
3.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

Recommended Citation:
Shi, Bentao,Li, Xuesong,Chen, Jing,et al. Resiniferatoxin for treatment of lifelong premature ejaculation: A preliminary study[J]. INTERNATIONAL JOURNAL OF UROLOGY,2014,21(9):923-926.
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