IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients
Wang Jun-feng1; Guan Zhen-peng1; Zhang Shao-long1; Pei Zheng1; Chen Ying-yu2; Pan Huan2
关键词rheumatoid arthritis programmed cell death 5 interleukin-17 pathogenesis
刊名CHINESE MEDICAL JOURNAL
2013-01-20
DOI10.3760/cma.j.issn.0366-6999.20122693
126期:2页:296-299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GENE-EXPRESSION ; APOPTOSIS ; PDCD5 ; CLASSIFICATION ; ASSOCIATION ; ANTAGONISTS ; LEUKEMIA ; CRITERIA ; CANCER
英文摘要

Background Programmed cell death 5 (PDCD5) is a novel apoptotic regulatory gene that promotes apoptosis in various tumor cells. Studies have shown that PDCD5 accelerates the apoptosis of synoviocytes in vitro, implying a potential role in rheumatoid arthritis (RA) pathogenesis. This study examined the expression of PDCD5 in serum and synovial fluid of RA patients, its effect on the expression of inflammatory cytokine, interleukin-17 (IL-17), and the assessment of disease activity in RA.

Methods PDCD5 and IL-17 levels in serum and synovial fluid from 18 patients with RA and 22 patients with osteoarthritis (OA) were detected using enzyme-linked immunosorbent assay (ELISA). Concentrations of serum PDCD5 in 40 healthy people were also detected as controls. As disease activity indices, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and X-ray grading scale were also evaluated.

Results Serum and synovial fluid PDCD5 levels in RA patients were significantly higher than those in OA and healthy controls. Serum PDCD5 level was inversely correlated to CRP and ESR, and was significantly higher in the RF negative group than in the positive group. PDCD5 level was also negatively correlated with IL-17 levels both in serum and synovial fluid of RA patients. However, differences in synovial fluid PDCD5 level from RA patients at different Larsen stages were not detectable.

Conclusions PDCD5 affects RA pathogenesis. Insufficient apoptosis of fibroblast-like synoviocytes and inflammatory cells in RA could increase the expression of PDCD5 protein. As PDCD5 levels correlated negatively with disease activity indices and IL-17 level, PDCD5 could become a target in the diagnosis and treatment of RA.

语种英语
WOS记录号WOS:000319632800018
项目编号81071447
资助机构National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65232
专题北京大学第二临床医学院
北京大学基础医学院
作者单位1.Peking Univ, Peoples Hosp, Arthrit Clin & Res Ctr, Beijing 100044, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang Jun-feng,Guan Zhen-peng,Zhang Shao-long,et al. Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients[J]. CHINESE MEDICAL JOURNAL,2013,126(2):296-299.
APA Wang Jun-feng,Guan Zhen-peng,Zhang Shao-long,Pei Zheng,Chen Ying-yu,&Pan Huan.(2013).Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients.CHINESE MEDICAL JOURNAL,126(2),296-299.
MLA Wang Jun-feng,et al."Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients".CHINESE MEDICAL JOURNAL 126.2(2013):296-299.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang Jun-feng]的文章
[Guan Zhen-peng]的文章
[Zhang Shao-long]的文章
百度学术
百度学术中相似的文章
[Wang Jun-feng]的文章
[Guan Zhen-peng]的文章
[Zhang Shao-long]的文章
必应学术
必应学术中相似的文章
[Wang Jun-feng]的文章
[Guan Zhen-peng]的文章
[Zhang Shao-long]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。