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学科主题: 药学
题名:
Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats
作者: Li, Hai-Xia1; Han, Shu-Yan1; Wang, Xian-Wei2; Ma, Xu1; Zhang, Ke1; Wang, Li1; Ma, Zhi-Zhong1; Tu, Peng-Fei1
关键词: Carthamus tinctorius ; Carthamins yellow ; Hemorheological disorders ; Blood stasis
刊名: FOOD AND CHEMICAL TOXICOLOGY
发表日期: 2009-08-01
DOI: 10.1016/j.fct.2009.04.026
卷: 47, 期:8, 页:1797-1802
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Toxicology
研究领域[WOS]: Food Science & Technology ; Toxicology
关键词[WOS]: ASPIRIN RESISTANCE ; PLATELET-AGGREGATION ; FLOW ; DISEASE ; MICROCIRCULATION ; AGGREGABILITY ; COAGULATION ; SIMVASTATIN ; PARAMETERS ; FIBRINOGEN
英文摘要:

Hemorheological disorders may play an important role in the pathogenesis and development of many diseases. Blood stasis, i.e. the decrease of blood flow velocity, indicates hemorheological abnormalities. The carthamins yellow (CY), isolated from Carthamus tinctorius L., has been extensively used as a natural food colorant. We investigated the effects of CY on a blood stasis model, which was obtained by placing rats in ice-cold water during the time interval between two injections of epinephrine. The results demonstrated that the CY significantly decreased the whole blood viscosity, plasma viscosity, and erythrocyte aggregation index, which were increased in the blood stasis model. Hematocrit and platelet aggregation were reduced, while prothrombin time was delayed with increasing doses of CY. Therefore, CY administration might provide the additional benefit of increasing blood fluidity by lowering blood viscosity, which can be of great value in the prevention of hemorheological disorder-associated diseases in at risk patients. Meanwhile, the mild activities of antiplatelet aggregation and anticoagulation induced by CY should be considered, if these relatively untoward symptoms occurred when the hemorrhagic patients ate food colored by CY. However the small amounts used in food are highly unlikely to cause adverse effects. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30525043
项目资助者: National Science Found for Distinguished Young Scholars of China
WOS记录号: WOS:000269100700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65242
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biophys, Sch Basic Med Sci,Hemorheol Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Hai-Xia,Han, Shu-Yan,Wang, Xian-Wei,et al. Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2009,47(8):1797-1802.
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