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Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer
Qiao, QL; Ramadani, M; Gansauge, S; Gansauge, F; Leder, G; Beger, HG
关键词beta-catenin pancreatic cancer survival
刊名INTERNATIONAL JOURNAL OF CANCER
2001-05-20
95期:3页:194-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]E-CADHERIN EXPRESSION ; BREAST-CANCER ; COLORECTAL-CANCER ; COLON-CARCINOMA ; CELL-ADHESION ; MUTATIONS ; SURVIVAL ; ACTIVATION ; GENE ; IMMUNOREACTIVITY
英文摘要

beta -Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays also a role in intracellular signaling and can function as an oncogene when it binds to the T-cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the nucleus. We evaluated the immunohistochemical expression pattern of beta -catenin in relationship with cyclin D1 overexpression, tumor grade, clinicopathologic parameters and patients′ survival in 43 ductal adenocarcinomas of the pancreas and 5 normal pancreatic tissues. We were able to show that, both reduced membranous beta -catenin expression (25 of 43, 58.1%) and accumulation of beta -catenin in the cytoplasm (28 of 43, 65.1%) correlated significantly with cyclin DI overexpression (both p < 0.0005), Furthermore, we could show a clear correlation between reduced membranous expression and ectopic cytoplasmic expression of -catenin (p < 0.0005), Among patients with carcinomas showing no cytoplasmic expression, the 1-year survival was 86.6% whereas among patients with carcinomas showing cytoplasmic expression only 35.7% survived 1 year (p < 0.01), Co-precipitation experiments revealed reduced beta -catenin bound to the E-cadherin-catenin complex in pancreatic tumor tissues compared with normal pancreatic tissues. These results suggest that beta -catenin mar be involved in the tumorigenesis of pancreatic cancer and exhibited its effects mainly by the transactivation of cyclin D1, (C) 2001 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000168662500011
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65246
专题北京大学第一临床医学院_普通外科
作者单位1.Univ Ulm, Dept Gen Surg, Div Mol Oncol, D-89075 Ulm, Germany
2.Beijing Med Univ, Teaching Hosp 1, Dept Gen Surg, Beijing 100083, Peoples R China
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Qiao, QL,Ramadani, M,Gansauge, S,et al. Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer[J]. INTERNATIONAL JOURNAL OF CANCER,2001,95(3):194-197.
APA Qiao, QL,Ramadani, M,Gansauge, S,Gansauge, F,Leder, G,&Beger, HG.(2001).Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer.INTERNATIONAL JOURNAL OF CANCER,95(3),194-197.
MLA Qiao, QL,et al."Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer".INTERNATIONAL JOURNAL OF CANCER 95.3(2001):194-197.
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