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Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia
Ruan Guo-Rui; Qin Ya-Zhen; Chen Shan-Shan; Li Jin-Lan; Ma Xi; Chang Yan; Wang Ya-Zhe; Fu Jia-Yu; Liu Yan-Rong
关键词acute myeloid leukemia (AML) chronic myeloid leukemia (CML) programmed cell death 5 (PDCD5) real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) apoptosis imatinib mesylate
刊名LEUKEMIA RESEARCH
2006-09-01
DOI10.1016/j.leukres.2005.12.028
30期:9页:1159-1165
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]CHRONIC MYELOGENOUS LEUKEMIA ; APOPTOSIS ; PROFILES ; CARCINOMA ; DIAGNOSIS ; CANCER ; TFAR19
英文摘要

To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells than in normal donor marrow cells. A negative correlation was found between relative levels of PDCD5 and BCR/ABL expression in all CML patients and in CML patients in the advanced phase. Treatment with the ABL tyrosine kinase inhibitor Imatinib mesylate increased PDCD5 expression in K562 and MEG-01 cells. These findings suggest that abnormal expression of PDCD5 in leukemia may be involved in the pathomechanism of AML and CML. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000239620500018
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65247
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
3.Peking Univ, Sch Basic Med, Dept Immunol, Ctr Human Dis Genom, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ruan Guo-Rui,Qin Ya-Zhen,Chen Shan-Shan,et al. Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia[J]. LEUKEMIA RESEARCH,2006,30(9):1159-1165.
APA Ruan Guo-Rui.,Qin Ya-Zhen.,Chen Shan-Shan.,Li Jin-Lan.,Ma Xi.,...&Liu Yan-Rong.(2006).Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia.LEUKEMIA RESEARCH,30(9),1159-1165.
MLA Ruan Guo-Rui,et al."Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia".LEUKEMIA RESEARCH 30.9(2006):1159-1165.
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