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学科主题: 临床医学
题名:
Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia
作者: Ruan Guo-Rui; Qin Ya-Zhen; Chen Shan-Shan; Li Jin-Lan; Ma Xi; Chang Yan; Wang Ya-Zhe; Fu Jia-Yu; Liu Yan-Rong
关键词: acute myeloid leukemia (AML) ; chronic myeloid leukemia (CML) ; programmed cell death 5 (PDCD5) ; real-time quantitative reverse transcription ; polymerase chain reaction (RQ-RT-PCR) ; apoptosis ; imatinib mesylate
刊名: LEUKEMIA RESEARCH
发表日期: 2006-09-01
DOI: 10.1016/j.leukres.2005.12.028
卷: 30, 期:9, 页:1159-1165
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: CHRONIC MYELOGENOUS LEUKEMIA ; APOPTOSIS ; PROFILES ; CARCINOMA ; DIAGNOSIS ; CANCER ; TFAR19
英文摘要:

To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells than in normal donor marrow cells. A negative correlation was found between relative levels of PDCD5 and BCR/ABL expression in all CML patients and in CML patients in the advanced phase. Treatment with the ABL tyrosine kinase inhibitor Imatinib mesylate increased PDCD5 expression in K562 and MEG-01 cells. These findings suggest that abnormal expression of PDCD5 in leukemia may be involved in the pathomechanism of AML and CML. (c) 2006 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000239620500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65247
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
3.Peking Univ, Sch Basic Med, Dept Immunol, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Ruan Guo-Rui,Qin Ya-Zhen,Chen Shan-Shan,et al. Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia[J]. LEUKEMIA RESEARCH,2006,30(9):1159-1165.
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