IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Alterations in hemorheological properties of erythrocytes in nude mice with erythroleukemia and the treatment effects of etoposide
Xu, XF; Zeng, Z; Yao, WJ; Sun, DG; Ka, WB; Zhou, SP; Wen, ZY
关键词erythroleukemia murine erythroleukemia cell line etoposide hemorheology
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2005
33期:4页:347-361
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]SHEAR-FLOW FIELD ; LOW-VISCOSITY ; RBC MEMBRANE ; CELLS ; ORIENTATION ; LEUKEMIA ; DISEASE ; DEFORMABILITY ; DEFORMATION
英文摘要

The purpose of this study was to examine the changes of hemorheological properties of erythrocytes in the nude mice with erythroleukemia and the treatment effects of etoposide (VP16). Thirty mice were randomly divided into three groups: the control group (C group), injected with 1 ml saline solution, the MEL group (M group) injected with 1 ml MEL (murine erythroleukemia cell line) and the MEL + VP16 group (V group) injected with 1 ml MEL and from the 8th day after injection, 20 mu l VP16 (1 mu g/mu l) was injected intraperitoneally every five days. One week after MEL injection, erythroblastic cells increased in the bone marrow and proerythroblasts were found in the peripheral blood, suggesting that erythroleukemia was induced. Abnormalities were also found in spleens and livers later. At around twenty days after injection, the mice in M group died and about four weeks after injection, the mice in V group also died. Compared with C group, the hemorheological indexes [the deformation index DI, orientation index (DIor), and the small deformation index (DId)], electrophoretic mobility, membrane fluidity as well as osmotic fragility of red blood cells (RBC) in M and V groups changed significantly. But after VP16 administration, the changes of above parameters in V group were less significant than those of M group. The results above suggested that intraperitoneal injection of MEL cells could cause erythroleukemia in nude mice, VP16 could alleviate the erythroleukemia symptom and improve the hemorheological properties, and could prolong V group nude mice survival.

语种英语
WOS记录号WOS:000234352800005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65248
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Expt Anim, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, XF,Zeng, Z,Yao, WJ,et al. Alterations in hemorheological properties of erythrocytes in nude mice with erythroleukemia and the treatment effects of etoposide[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2005,33(4):347-361.
APA Xu, XF.,Zeng, Z.,Yao, WJ.,Sun, DG.,Ka, WB.,...&Wen, ZY.(2005).Alterations in hemorheological properties of erythrocytes in nude mice with erythroleukemia and the treatment effects of etoposide.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,33(4),347-361.
MLA Xu, XF,et al."Alterations in hemorheological properties of erythrocytes in nude mice with erythroleukemia and the treatment effects of etoposide".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 33.4(2005):347-361.
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