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学科主题: 基础医学
题名:
Alterations in hemorheological properties of erythrocytes in nude mice with erythroleukemia and the treatment effects of etoposide
作者: Xu, XF; Zeng, Z; Yao, WJ; Sun, DG; Ka, WB; Zhou, SP; Wen, ZY
关键词: erythroleukemia ; murine erythroleukemia cell line ; etoposide ; hemorheology
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2005
卷: 33, 期:4, 页:347-361
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: SHEAR-FLOW FIELD ; LOW-VISCOSITY ; RBC MEMBRANE ; CELLS ; ORIENTATION ; LEUKEMIA ; DISEASE ; DEFORMABILITY ; DEFORMATION
英文摘要:

The purpose of this study was to examine the changes of hemorheological properties of erythrocytes in the nude mice with erythroleukemia and the treatment effects of etoposide (VP16). Thirty mice were randomly divided into three groups: the control group (C group), injected with 1 ml saline solution, the MEL group (M group) injected with 1 ml MEL (murine erythroleukemia cell line) and the MEL + VP16 group (V group) injected with 1 ml MEL and from the 8th day after injection, 20 mu l VP16 (1 mu g/mu l) was injected intraperitoneally every five days. One week after MEL injection, erythroblastic cells increased in the bone marrow and proerythroblasts were found in the peripheral blood, suggesting that erythroleukemia was induced. Abnormalities were also found in spleens and livers later. At around twenty days after injection, the mice in M group died and about four weeks after injection, the mice in V group also died. Compared with C group, the hemorheological indexes [the deformation index DI, orientation index (DIor), and the small deformation index (DId)], electrophoretic mobility, membrane fluidity as well as osmotic fragility of red blood cells (RBC) in M and V groups changed significantly. But after VP16 administration, the changes of above parameters in V group were less significant than those of M group. The results above suggested that intraperitoneal injection of MEL cells could cause erythroleukemia in nude mice, VP16 could alleviate the erythroleukemia symptom and improve the hemorheological properties, and could prolong V group nude mice survival.

语种: 英语
WOS记录号: WOS:000234352800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65248
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Expt Anim, Beijing 100083, Peoples R China

Recommended Citation:
Xu, XF,Zeng, Z,Yao, WJ,et al. Alterations in hemorheological properties of erythrocytes in nude mice with erythroleukemia and the treatment effects of etoposide[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2005,33(4):347-361.
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